Radionuclide Risk Coefficient Uncertainty Distributions for Use in Performance Assessments - 19156

Conference · Mon Jul 01 04:00:00 EDT 2019

OSTI ID:23002958

Schaupp, Christopher M.; Broms, Kristin; Gains-Germain, Leslie; Lee, Robert C.; Perona, Ralph; Black, Paul ^[1]

---

1. Neptune and Company, Inc., Lakewood, CO (United States)

Traditionally, radiation dose has been used as the regulatory criterion for decision making in performance assessments (PAs), despite the concept of cancer risk arguably being a more easily understood endpoint than dose for the public, and a preferable metric for decision analysis. However, the United States Environmental Protection Agency (EPA) has developed risk parameters for use in risk assessments and PAs in the form of radionuclide-specific risk coefficients, or RCs, which are published in various Federal Guidance Reports (FGRs). RCs are employed as scalars to convert environmental radionuclide exposure (via ingestion, inhalation, and external exposure) estimates to incremental lifetime cancer risk (ILCR). ILCR is the additional cancer risk averaged over a lifetime, over-and-above all-cause cancer risk, associated with carcinogen exposure. Uncertainties associated with RCs are discussed in FGR 13 and in a joint report published by EPA and Oak Ridge National Laboratory, but statistical distributions for the RCs were not directly developed. The uncertainty assessments in the EPA/ONRL report were based on dosimetric modeling and elicitation of nine experts. From these sources, five uncertainty categories were defined based on ratios of the 5. and 95. quantiles of uncertainty. Thus, the representations of uncertainty defined by EPA/ORNL are not distributions in a traditional sense. Furthermore, the authors only addressed uncertainty in RCs for inhalation and ingestion pathways. We develop a methodology for assigning statistical distributions to EPA's published mortality RC values (i.e. to estimate the probability of dying from radiation-induced cancers) for the inhalation (slow, medium, and fast absorption types), ingestion (water, food, and soil), and external exposure pathways associated with all cancer types. We employed the same dosimetric concepts and assumptions as EPA/ORNL, including cancer risk (dose-response) distributional information from a previous expert elicitation, which was also employed by EPA/ORNL in their work. We assumed that uncertainty in RCs can be described by lognormal distributions based on the modeling conducted previously by EPA/ORNL, and that point estimates tabulated in FGR 13 represent median values of the distributions. We also extended EPA/ORNL's uncertainty ratios to statistical distributions for external exposure RCs. The results are a set of radionuclide-specific distributions that are applicable in PAs that focus on cancer mortality. These distributions are currently and will subsequently be employed in PAs at various sites, in addition to the required regulatory dose limits. Quantification of ILCRs and associated uncertainty in PAs will provide regulators and the public with additional information for good decision making. Future directions include further refinement of the distributions and development of statistical distributions for morbidity RCs, which are used to estimate the probability of developing, but not necessarily dying as a result of, radiation-induced cancer. (authors)

• Research Organization: WM Symposia, Inc., PO Box 27646, 85285-7646 Tempe, AZ (United States)
• OSTI ID: 23002958
• Report Number(s): INIS-US--21-WM-19156
• Country of Publication: United States
• Language: English

Related Subjects

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE WASTES FROM NUCLEAR FACILITIES
CARCINOGENS
COMPUTERIZED SIMULATION
DISEASE INCIDENCE
DOSE LIMITS
ENVIRONMENTAL PROTECTION
INGESTION
INHALATION
NEOPLASMS
ORNL
RADIATION DOSES
RADIATION HAZARDS
RADIOISOTOPES
RISK ASSESSMENT
SOILS
US EPA