Assessment of left ventricular contraction patterns using gated SPECT MPI to predict cardiac resynchronization therapy response

Journal Article · Sat Dec 15 04:00:00 EST 2018 · Journal of Nuclear Cardiology (Online)

DOI:https://doi.org/10.1007/S12350-017-0949-1· OSTI ID:22962198

Tao, Ningchao; Qiu, Yuanhao ^[1]; Tang, Haipeng ^[2]; Qian, Zhiyong; Wu, Hongping; Zhu, Rui; Wang, Yao; Hou, Xiaofeng ^[1]; Zhou, Weihua ^[2]; Zou, Jiangang ^[1]

---

1. The First Affiliated Hospital of Nanjing Medical University, Department of Cardiology (China)
2. University of Southern Mississippi, School of Computing (United States)

Background: The U-shaped left ventricular (LV) contraction pattern, identified by MRI or echocardiography, is associated with improved CRT response. Gated SPECT MPI can measure both myocardial viability and mechanical dyssynchrony in a single scan. The aim of this study is to examine the relationship of the LV contraction pattern and the response of CRT in patients with left bundle branch block (LBBB). Methods: Fifty-eight patients who met CRT guidelines and who had pre-CRT MPI were enrolled. Myocardial segments with tracer uptake < 50% of maximum were considered as scar. The LV contraction pattern was considered as U-shaped or non-U-shaped (U-shaped has a block line in the direction of contraction propagation). CRT response was defined as an increase in left ventricular ejection fraction ≥ 5% after 6-month follow-up. Results: Twenty-eight patients (48%) had a U-shaped contraction pattern and thirty patients (52%) had a non-U-shaped contraction pattern. The U-shaped group showed a significantly higher response rate than the non-U-shaped group (90% vs. 57%; P = 0.005). By univariate and multivariate logistic regression analysis, the U-shaped pattern was an independent predictor of CRT response. Conclusion: Non-invasive gated SPECT MPI can characterize LV mechanical contraction patterns. A U-shaped contraction pattern identified is associated with improved CRT response. This may prove useful for improved patient selection for CRT.

• OSTI ID: 22962198
• Journal Information: Journal of Nuclear Cardiology (Online), Journal Name: Journal of Nuclear Cardiology (Online) Journal Issue: 6 Vol. 25; ISSN 1532-6551
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
HEART FAILURE
MULTIVARIATE ANALYSIS
NMR IMAGING
PATIENTS
RECOMMENDATIONS
REGRESSION ANALYSIS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
UPTAKE