Preparation of Chitosan, Sodium Alginate, Gelatin and Collagen Biodegradable Sponge Composites and their Application in Wound Healing and Curcumin Delivery

Journal Article · Sun Dec 15 04:00:00 EST 2019 · Journal of Polymers and the Environment

DOI:https://doi.org/10.1007/S10924-019-01559-Z· OSTI ID:22959262

Naghshineh, Negar; Tahvildari, Kambiz; Nozari, Maryam ^[1]

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1. Islamic Azad University (Iran, Islamic Republic of)

This research aimed to produce three chitosan-based biodegradable sponge composites from collagen, gelatin, and sodium alginate and through addition of curcumin to investigate their biological effects on wound healing. To this end, the Chitosan-Collagen-Curcumin (Chs, Col, Cur), Chitosan-Gelatin-Curcumin (Chs, Gel, Cur), and Chitosan-Alginate-Curcumin (Chs, Alg, Cur) sponge composites were prepared and subject to FT-IR, SEM, TGA, water absorption, biodegradability, wound healing and anti-bacterial analyses. Based on the results, the highest and lowest water absorptions were associated with Chitosan-Alginate-Curcumin and Chitosan-Collagen-Curcumin composites, respectively. Moreover, according to the SEM images, the highest porosity and the largest cavity size were associated with the Chitosan-Alginate-Curcumin composite. The biodegradability analysis results revealed that Chitosan-Alginate-Curcumin was completely destroyed in 4 days, while the Chitosan-Collagen-Curcumin composite showed the lowest level of destruction. Moreover, the highest amount of curcumin was released by the Chitosan-Gelatin-Curcumin composite which happened during the first hour. Finally, the highest wound healing effect was achieved within a 10-day period using the Chitosan-Gelatin-Curcumin composite, completely healing the wound on the mouse skin. On the other hand, the lowest effect was associated with the Chitosan-Alginate-Curcumin composite. The antibacterial tests suggested that all composites exhibited anti-bacterial capabilities, the highest level of which was associated with the Chitosan-Gelatin-Curcumin composite. Moreover, based on the histological tests, the fastest tissue repair process with the highest quality was achieved using the Chitosan-Gelatin-Curcumin sponge composite.

• OSTI ID: 22959262
• Journal Information: Journal of Polymers and the Environment, Journal Name: Journal of Polymers and the Environment Journal Issue: 12 Vol. 27; ISSN 1566-2543
• Country of Publication: United States
• Language: English

Related Subjects

36 MATERIALS SCIENCE
ALGINATES
ANIMAL TISSUES
BIOLOGICAL EFFECTS
COLLAGEN
CURCUMIN
DRUG DELIVERY
FOURIER TRANSFORM SPECTROMETERS
GELATIN
INFRARED SPECTRA
MICE
OLIGOSACCHARIDES
POROSITY
SCANNING ELECTRON MICROSCOPY
SODIUM
THERMAL GRAVIMETRIC ANALYSIS
WOUNDS