The high matrix acquisition technique for imaging of atherosclerotic plaque inflammation in fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography with time-of-flight: Phantom study

Journal Article · Tue Aug 15 00:00:00 EDT 2017 · Journal of Nuclear Cardiology (Online)

DOI:https://doi.org/10.1007/S12350-016-0510-7· OSTI ID:22955095

Suda, Masaya ^[1]; Kiriyama, Tomonari ^[2]; Ishihara, Keiichi ^[1]; Onoguchi, Masahisa ^[3]; Kobayashi, Yasuhiro ^[2]; Sakurai, Minoru ^[1]; Shibutani, Takayuki ^[3]; Kumita, Shin-ichiro ^[2]

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1. Nippon Medical School, Clinical Imaging Center for Healthcare (Japan)
2. Nippon Medical School, Department of Radiology (Japan)
3. Kanazawa University, Department of Quantum Medical Technology (Japan)

Background: Motion artifact and partial volume effect caused underestimation of coronary plaque inflammation. This study evaluated the high matrix acquisition technique using time-of-flight (TOF) positron emission tomography/computed tomography for imaging of atherosclerotic plaque inflammation with fluorine-18 fluorodeoxyglucose in small and moving phantoms. Methods and Results: All images were reconstructed using a conventional algorithm without TOF (4 × 4 × 4 mm{sup 3} voxel size) and a high matrix algorithm with TOF (2 × 2 × 2 mm{sup 3} voxel size). Microsphere phantoms of 10, 7.9, 6.2, 5.0, and 4.0 mm diameters were acquired in 3-dimensional list-mode for 30 minutes. A heart phantom mimicking cardiac motion consisted of a hot spot simulating a plaque (φ 4 mm, φ 2 mm) on the outside of the left ventricle. In the microsphere and heart phantom study, visual discrimination, maximum activity, and target-to-background ratio using the high matrix algorithm with TOF were better than those using the conventional algorithm without TOF. Conclusion: The high matrix algorithm with TOF improves detection of small targets in phantoms.

• OSTI ID: 22955095
• Journal Information: Journal of Nuclear Cardiology (Online), Vol. 24, Issue 4; Other Information: Copyright (c) 2017 American Society of Nuclear Cardiology; Country of input: International Atomic Energy Agency (IAEA); ISSN 1532-6551
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ALGORITHMS
CORONARIES
FLUORINE 18
FLUORODEOXYGLUCOSE
HEART
INFLAMMATION
MICROSPHERES
PHANTOMS
POSITRON COMPUTED TOMOGRAPHY
THREE-DIMENSIONAL CALCULATIONS
TIME-OF-FLIGHT METHOD