Performances of ionic liquid matrices with butyl ammonium counterion for matrix-assisted laser desorption/ionization mass spectrometric detection and analysis of sucralfate

Journal Article · Wed Jul 01 04:00:00 EDT 2020 · Journal of Carbohydrate Chemistry

DOI:https://doi.org/10.1080/07328303.2019.1669633· OSTI ID:22946932

Petković, Marijana; Leopold, Jenny; Popović, Iva A.; Dimić, Dušan; Ilić, Jelica; others, and

In this work, the performances of two ionic liquid matrices (ILMs) with the same ammonium counterpart for mass spectrometric analysis of the insoluble and soluble sucralfate were compared. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) was performed assisted by the butylammonium salts of α-cyano-hydroxycinnamic acid (CHCAB) and 2,5-dihydroxybenzoic acid (DHBB). CHCAB has a higher IE than DHBB, but better optical properties. CHCAB is more suitable for the analysis of sucralfate, although molecular ions of both compounds were detectable only with low intensities. Thus, optical properties of ILMs are crucial to enhance the sensitivity of MALDI MS detection of polysulfated oligosaccharides. © 2019, © 2019 Taylor & Francis Group, LLC.

• OSTI ID: 22946932
• Journal Information: Journal of Carbohydrate Chemistry, Journal Name: Journal of Carbohydrate Chemistry Journal Issue: 1 Vol. 39; ISSN 0732-8303
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
60 APPLIED LIFE SCIENCES
DESORPTION
DETECTION
IONIZATION
LASERS
MASS SPECTROSCOPY
MATRICES
MOLECULAR IONS
MOLTEN SALTS
OPTICAL PROPERTIES