N-Glycosylation in progression of skin cancer

Journal Article · Sat Jun 15 04:00:00 EDT 2019 · Medical Oncology (Online)

DOI:https://doi.org/10.1007/S12032-019-1270-4· OSTI ID:22938417

Tang, Ling ^[1]; Chen, Xiaoping ^[2]; Zhang, Xu; Guo, Yeye; Su, Juan; Zhang, Jianglin; Peng, Cong; Chen, Xiang ^[1]

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1. Central South University, Department of Dermatology, Xiangya Hospital (China)
2. Central South University, Department of Clinical Pharmacology, Xiangya Hospital (China)

Skin cancer can be classified as cutaneous malignant melanoma, basal cell carcinoma, and squamous cell carcinoma. Due to the high level of morbidity and mortality, skin cancer has become a global public health issue worldwide while the pathogenesis of skin cancer is still unclear. It is necessary to further identify the pathogenesis of skin cancer and find candidate targets to diagnose and treat skin cancer. A variety of factors are known to be associated with skin cancer including N-glycosylation, which partly explained the malignant behaviors of skin cancer. In this review, we retrieved databases such as PubMed and Web of Science to elucidate its relationship between glycosylation and skin cancer. We summarized some key glycosyltransferases and proteins during the process of N-glycosylation related to skin cancer, which was helpful to unmask the additional mechanism of skin cancer and find some novel targets of skin cancer.

• OSTI ID: 22938417
• Journal Information: Medical Oncology (Online), Journal Name: Medical Oncology (Online) Journal Issue: 6 Vol. 36; ISSN 1559-131X
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
DIAGNOSIS
DISEASE INCIDENCE
MELANOMAS
MORTALITY
PATHOGENESIS
PROTEINS
PUBLIC HEALTH
REVIEWS