Expression of cellular apoptosis susceptibility (CAS) in the human testis and testicular germ cell tumors

Journal Article · Mon Jul 15 00:00:00 EDT 2019 · Medical Oncology (Online)

DOI:https://doi.org/10.1007/S12032-019-1281-1· OSTI ID:22938405

Liu, Jianni; Ye, Mei ^[1]; Han, Ruigang ^[2]; Gui, Yaoting; Li, Xiaofeng ^[3]; Zhang, Han; Wang, Xin; Guo, Haoran ^[4]; Li, Fanghong; Zhao, Allan Zijian ^[1]; Guan, Kunping ^[4]; Chen, Hao ^[1]

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1. Guangdong University of Technology, School of Biomedical and Pharmaceutical Sciences (China)
2. Reproductive Medicine Center of The 306th Hospital of PLA (China)
3. Peking University Shenzhen Hospital, Department of Laboratory Medicine (China)
4. Second Hospital of ShanXi Medical University (China)

Testicular germ cell tumors are the most frequent malignancies found in men between 15 and 44 years old. Although cellular apoptosis susceptibility (CAS) was demonstrated to be upregulated in breast cancer and colon cancer, the expression of CAS in the human testis and testicular germ cell tumors remained elusive. In the present study, CAS-positive signals were detected in the normal testicular tissues, cancer adjacent normal testicular tissues, seminoma, yolk sac tumor, and teratoma. Interestingly, the expression level of CAS in testicular germ cell tumors (TGCTs) (but not seminoma) was significantly lower than that of human testicular tissues and cancer adjacent normal testicular tissues, suggesting that decreased CAS contributed to the progression of TGCTs. Notably, the expression of CAS in seminoma was significantly higher than that of in the non-seminomas, consistent with the results from TCGA database. Furthermore, the localization of CAS is mainly restricted in the nucleus in the lesions of normal human testicular tissue and cancer adjacent normal testicular tissue. Although the expression of CAS was not significantly different between normal testicular tissue and seminoma, CAS was more enriched in cytoplasm in seminoma compared to the normal, cancer adjacent tissue and other types of TGCTs. The current results demonstrated reduced expression of CAS in the human testicular germ cell tumors and the CAS translocation from the nuclear to cytoplasm in seminoma, thereby supporting a possible role in normal testis function and in the development of seminoma.

• OSTI ID: 22938405
• Journal Information: Medical Oncology (Online), Journal Name: Medical Oncology (Online) Journal Issue: 7 Vol. 36; ISSN 1559-131X
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
APOPTOSIS
CYTOPLASM
GERM CELLS
LARGE INTESTINE
MAMMARY GLANDS
MEN
NEOPLASMS
TESTES