Blood levels of endocrine-disrupting metals and prevalent breast cancer among US women
Journal Article
·
· Medical Oncology (Online)
- Mercer University School of Medicine, Department of Community Medicine (United States)
- Fort Valley State University, Department of Mathematics and Computer Science (United States)
A growing body of evidence has pointed to a role of environmental chemical exposures in breast cancer etiology. This study was to examine the association between exposure to the endocrine-disrupting metals, including cadmium (Cd), lead (Pb), and mercury (Hg), and breast cancer in US women. A nationally representative subsample of 9260 women aged ≥ 20 years in the 2003–2012 National Health and Nutrition Examination Survey was analyzed for the association of blood levels of these metals with prevalent breast cancer using multivariate logistic regression models. Of the study participants, 284 women (weighted prevalence, 2.8%) were self-reported being diagnosed with breast cancer during 2003–2012. Breast cancer women showed significantly elevated blood levels of Cd and Pb, but not Hg. After adjusting for potential confounders, we found that women in all of the higher quartiles of blood lead levels (BLLs) had significantly increased odds ratio of prevalent breast cancer compared with those in the lowest quartile. However, a significant association with prevalent breast cancer was not seen with blood levels of either Cd or Hg. Our study demonstrates a potential relationship between lead exposure, measured as BLLs, and female breast cancer. Additional epidemiologic and mechanistic studies would further explore these interactions and elucidate the potential role of lead exposure in breast cancer etiology.
- OSTI ID:
- 22938368
- Journal Information:
- Medical Oncology (Online), Journal Name: Medical Oncology (Online) Journal Issue: 1 Vol. 37; ISSN 1559-131X
- Country of Publication:
- United States
- Language:
- English
Similar Records
Associations between cadmium exposure and circulating levels of sex hormones in postmenopausal women
Prevalence of elevated blood lead levels among pregnant women and sources of lead exposure in rural Bangladesh: A case control study
Relation between residential magnetic fields, light-at-night, and nocturnal urine melatonin levels in women: Volume 2 -- Magnetic field exposure analysis. Final report
Journal Article
·
Wed Oct 15 00:00:00 EDT 2014
· Environmental Research
·
OSTI ID:22447544
Prevalence of elevated blood lead levels among pregnant women and sources of lead exposure in rural Bangladesh: A case control study
Journal Article
·
Mon Oct 15 00:00:00 EDT 2018
· Environmental Research
·
OSTI ID:23105878
Relation between residential magnetic fields, light-at-night, and nocturnal urine melatonin levels in women: Volume 2 -- Magnetic field exposure analysis. Final report
Technical Report
·
Fri Oct 31 23:00:00 EST 1997
·
OSTI ID:355014