Synthesis and antitumor activity evaluation of different 2,5-dialkyloxazolopyrano[3,2-c]quinolinone derivatives
Journal Article
·
· Medicinal Chemistry Research (Print)
A new interesting family of 2,5-dialkyloxazolopyrano[3,2-c]quinolinone derivatives 4a-l were synthesized in good yields using a convenient and successful method. Structures of all compounds were achieved by elemental analyses, IR, {sup 1}H NMR, {sup 13}C NMR, and mass techniques. The tetracyclic homologues 4a-l were evaluated for antitumor activity and cytotoxicity against a board of three human cancer cell lines (HepG-2, MCF-7, and HCT-116). The cells were treated with these compounds at differentiable dosages, and cell viability was determined. Significant anticancer activities were observed in vitro for some members of the series related to 5-fluorouracil and compounds 4c and 4f showed potent cytotoxic effect, that creates these compounds were disclosed as the most applicable anticancer agents against different cancer cell lines.
- OSTI ID:
- 22936219
- Journal Information:
- Medicinal Chemistry Research (Print), Journal Name: Medicinal Chemistry Research (Print) Journal Issue: 1 Vol. 28; ISSN 1054-2523
- Country of Publication:
- United States
- Language:
- English
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