Synthesis and bioassay of a new class of disubstituted 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles
Journal Article
·
· Medicinal Chemistry Research (Print)
- Sri Venkateswara University, Department of Chemistry (India)
A new class of aroylethenesulfonylmethyl styryl oxadiazoles/thiadiazoles/triazoles and arylsulfonylethenesulfonylmethyl styryl oxadiazoles/thiadiazoles/triazoles were synthesized from the synthetic intermediates E-aroylethenesulfonylacetic acid methyl ester, E-arylsulfonylethenesulfonylacetic acid methyl ester and substituted cinnamic acids adopting conventional and ultrasonication methodologies. All the synthesized compounds were obtained in higher yields and in shorter reaction times in ultrasound irradiation method when compared with conventional method. The structures of all the compounds were characterized by IR, {sup 1}H NMR, {sup 13}C NMR and mass spectra. All the title compounds were tested for antimicrobial activity. The arylsulfonylethenesulfonylmethyl styryl azoles displayed higher antimicrobial activity than the aroylethenesulfonylmethyl styryl azoles. The compounds having triazole moiety showed greater activity than those with oxadiazole and thiadiazole. Amongst all the tested compounds unsubstituted and chloro substituted arylsulfonylethenesulfonyl methyl styryl triazoles are identified as potential antimicrobial agents particularly against B. subtilis and P.chrysogenum. .
- OSTI ID:
- 22936185
- Journal Information:
- Medicinal Chemistry Research (Print), Journal Name: Medicinal Chemistry Research (Print) Journal Issue: 7 Vol. 28; ISSN 1054-2523
- Country of Publication:
- United States
- Language:
- English
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