Synthesis and anti-inflammatory activity of 1,2-3-substituted 2a1,4,5-triazacyclopenta[cd]indene derivatives

Journal Article · Sun Sep 01 04:00:00 EDT 2019 · Medicinal Chemistry Research (Print)

DOI:https://doi.org/10.1007/S00044-019-02386-6· OSTI ID:22936176

Sanivarapu, Sumalatha ^[1]; Vaddiraju, Namratha ^[2]; Velide, Lakshmi ^[3]

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1. Jawaharlal Nehru Technological University, Department of Chemistry (India)
2. Satavahana University, Department of Chemistry (India)
3. Kakatiya University, Department of Life Sciences (India)

The present study reports the synthesis of 1,2-3-substituted-2a1,4,5-triazacyclopenta[cd]indene derivatives. The synthetic methodology includes some of the prominent reaction steps as specified in sequence (i) Bromination of acetophenones (ii) Condensation of 2-bromo-1-(substituted phenyl) ethanone derivatives with 2-aminopyrimidine, and (iii) Coupling of imidazo[1,2-a]pyrimidine derivatives with 1,2-diaryl/diaklylethynes. The structures of the newly synthesized derivatives have been determined by {sup 1}H NMR, {sup 13}C NMR, LC-MS, and IR spectral analysis. Furthermore, these derivatives were screened for their preliminary anti-inflammatory activities using Carrageenan induced paw edema test method. These promising screening results suggested a huge potential for the molecular diversity from present compounds that can be inflated to better lead candidates.

• OSTI ID: 22936176
• Journal Information: Medicinal Chemistry Research (Print), Journal Name: Medicinal Chemistry Research (Print) Journal Issue: 9 Vol. 28; ISSN 1054-2523
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ACETOPHENONE
BROMIDES
BROMINATION
CARBON 13
EDEMA
HYDROGEN 1
INDENE
INFLAMMATION
NUCLEAR MAGNETIC RESONANCE
PYRIMIDINES
SYNTHESIS