Structural and Functional Analysis of the Spermatogenic Epithelium in Rats Exposed to Titanium Dioxide Nanoparticles
Journal Article
·
· Bulletin of Experimental Biology and Medicine
- Bashkir State University, Department of Human Physiology and General Biology, Faculty of Biology (Russian Federation)
- Kazan State Medical University, Department of Histology (Russian Federation)
We studied immunohistochemical and morphometric characteristics of the spermatogenic epithelium in rats against the background of peroral administration of nanoparticles containing titanium dioxide. Substantial degenerative changes in the spermatogenic epithelium were revealed: thinning, disorganization of layers, and detachment of sperm cells from the basement membrane. Immunohistochemical analysis revealed reduced proliferative activity and differentiation potential of epithelial cells, which was confirmed by changes in the expression of Ki-67 and c-kit markers. Our data attest to unfavorable effects of titanium dioxide nanoparticles on the structural and functional characteristics of the reproductive system in male rats leading to spermatogenesis disturbances.
- OSTI ID:
- 22927939
- Journal Information:
- Bulletin of Experimental Biology and Medicine, Journal Name: Bulletin of Experimental Biology and Medicine Journal Issue: 2 Vol. 166; ISSN BEXBAN; ISSN 0007-4888
- Country of Publication:
- United States
- Language:
- English
Similar Records
In vivo effects of endotoxin on DNA synthesis in rat nasal epithelium
Radiation Survival and Regeneration Characteristics of Spermatogenic Stem Cells of Mouse Testis
Reproductive toxicity of 2,4-toluenediamine in the rat. 2. Spermatogenic and hormonal effects
Journal Article
·
Tue Nov 30 23:00:00 EST 1993
· Microscopy Research and Technique; (United States)
·
OSTI ID:5346007
Radiation Survival and Regeneration Characteristics of Spermatogenic Stem Cells of Mouse Testis
Journal Article
·
Mon Dec 31 23:00:00 EST 1973
· Radiation Research
·
OSTI ID:4344709
Reproductive toxicity of 2,4-toluenediamine in the rat. 2. Spermatogenic and hormonal effects
Journal Article
·
Mon Dec 31 23:00:00 EST 1984
· J. Toxicol. Environ. Health; (United States)
·
OSTI ID:5575121