Contrast Agents Based on Iron Oxide Nanoparticles for Clinical Magnetic Resonance Imaging

Journal Article · Sat Jun 15 04:00:00 EDT 2019 · Bulletin of Experimental Biology and Medicine

DOI:https://doi.org/10.1007/S10517-019-04507-Y· OSTI ID:22927654

Ternovoi, S. K. ^[1]; Mazhuga, A. G. ^[2]; Chekhonin, V. P. ^[3]; Demikhov, E. I.; Pistrak, A. G.; Konstantinov, M. V.; Dmitriev, D. M. ^[4]; Myshkinis, B. Ya. ^[5]

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1. National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation (Russian Federation)
2. Biomedical Nanomaterials Laboratory, National University of Science and Technology MISIS (Russian Federation)
3. N. I. Pirogov Russian Research Medical University, Ministry of Health of the Russian Federation (Russian Federation)
4. P. N. Lebedev Physical Institute, Russian Academy of Sciences (Russian Federation)
5. Gelpik Company (Russian Federation)

Magnetic resonance imaging (MRI) is one of the most perspective methods of noninvasive visualization in medicine, and use of contrast agents significantly its potentialities extends. Iron oxide nanoparticles are promising contrast agents, but in fact all the data on their efficiency were obtained in high-field tomographs for experimental animals. We studied the possibility of using magnetic nanoparticles for MRI visualization of rat brain glioblastoma at the most common clinical field 1.5 T The data indicate the efficiency of iron oxide magnetic nanoparticles as contrast agents for 1.5 T MR tomographs.

• OSTI ID: 22927654
• Journal Information: Bulletin of Experimental Biology and Medicine, Journal Name: Bulletin of Experimental Biology and Medicine Journal Issue: 2 Vol. 167; ISSN BEXBAN; ISSN 0007-4888
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
BRAIN
CONTRAST MEDIA
GLIOMAS
IRON OXIDES
NANOPARTICLES
NMR IMAGING
RATS