Breast Density in a Contemporary Cohort of Women With Ductal Carcinoma In Situ (DCIS)

Journal Article · Tue Oct 15 04:00:00 EDT 2019 · Annals of Surgical Oncology (Online)

DOI:https://doi.org/10.1245/S10434-019-07479-5· OSTI ID:22927574

Gooch, Jessica C.; Chun, Jennifer; Kaplowitz, Elianna ^[1]; Kurz, Emma ^[2]; Guth, Amber ^[1]; Lee, Jiyon ^[3]; Schnabel, Freya ^[1]

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1. New York University Langone Health, Division of Breast Surgical Oncology, Department of Surgery (United States)
2. New York University School of Medicine (United States)
3. New York University Langone Health, Department of Radiology (United States)

Background: Mammographic breast density (MBD) is an independent risk factor for breast cancer. Information regarding the relationship of MBD and breast cancer biology in women with ductal carcinoma in situ (DCIS) is currently lacking. This study aimed to examine the clinicopathologic characteristics of DCIS in women stratified by MBD. Methods: A retrospective review was performed to identify women with pure DCIS who underwent preoperative mammography between 2010 and 2018. Clinicopathologic and demographic data were collected. For the purpose of analysis, MBD was categorized as “non-dense” (Breast Imaging-Reporting and Data System [BI-RADS] density categories A and B) or “dense” (BI-RADS C and D) according to its identification in radiology reports. Results: Of 3227 patients with a breast cancer diagnosis enrolled in the institutional Breast Cancer Database during the study period, 658 (20%) had pure DCIS. Of these 658 patients, 42% had non-dense breasts, and 58% had dense breasts. Most lesions were non-palpable (92%) and detected by mammography (84%). Patients with dense breasts were more likely to be younger at the time of diagnosis (p < 0.001), premenopausal (p < 0.001), and Asian (p = 0.018), and to have higher-grade disease (p = 0.006; Table 2). Family history, BRCA status, parity, mammogram frequency, palpability, method of presentation, lesion size, hormone receptor status, comedo histology, and recurrence did not differ significantly between the two groups (Table 1). The median follow-up period was 7.1 years. Conclusion: Women with pure DCIS and higher MBD are more likely to be younger at the time of diagnosis, premenopausal, and Asian, and to present with higher-grade disease. Further research on the relationship of age, MBD, and tumor biology in DCIS is warranted.

• OSTI ID: 22927574
• Journal Information: Annals of Surgical Oncology (Online), Journal Name: Annals of Surgical Oncology (Online) Journal Issue: 11 Vol. 26; ISSN 1534-4681
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BIOMEDICAL RADIOGRAPHY
CARCINOMAS
DIAGNOSIS
MAMMARY GLANDS
WOMEN