Perioperative Use of Nonsteroidal Anti-inflammatory Drugs Decreases the Risk of Recurrence of Cancer After Colorectal Resection: A Cohort Study Based on Prospective Data
- Zealand University Hospital and University of Copenhagen, Department of Surgery, Center for Surgical Science (CSS), Enhanced Perioperative Oncology Consortium (Denmark)
- Copenhagen University Hospital Herlev, Department of Surgery, Center for Robotics and Minimally Invasive Surgery (Denmark)
Background: Perioperative use of nonsteroidal anti-inflammatory drugs (NSAIDs) is known to reduce inflammatory response in relation to surgery. Inflammation may promote recurrence of cancer, thus inhibition by use of NSAIDs could reduce recurrence after surgery. Objective: The aim of this study was to examine the association between perioperative use of NSAIDs and cancer recurrence, as well as disease-free survival (DFS) and mortality after colorectal cancer surgery. Methods: This was a cohort study based on data from a prospective clinical database, electronic medical records, and nationwide registers, and included patients from six major colorectal centers in Denmark. The primary outcome was cancer recurrence, while secondary outcomes included 5-year mortality and DFS. Results: Overall, 2308 patients undergoing colorectal cancer surgery between 1 January 2006 and 31 December 2009 were included. A total of 909 patients received at least 2 days of treatment with NSAIDs, of whom 702 (77.2%) received ibuprofen and 204 (22.4%) received diclofenac. Cox regression analysis adjusting for NSAIDs resulted in decreased recurrence risk (adjusted hazard ratio [HR{sub adjusted}] 0.84, 95% confidence interval [CI] 0.72–0.99; p = 0.042). Competing risk analysis confirmed the finding, with an HR{sub adjusted} of 0.76 (95% CI 0.60–0.97; p = 0.026). There was no significant effect on mortality or DFS. Sensitivity analysis of the effect of ibuprofen reported an HR{sub adjusted} of 0.83 (95% CI 0.70–1.00; p = 0.047). In restricted analyses of localized disease only (Union for International Cancer Control [UICC] I–II) and elective surgery only, no effect was found (localized: HR{sub adjusted} 0.81, 95% CI 0.62–1.06, p = 0.12; elective: HR{sub adjusted} 0.85, 95% CI 0.72–1.01, p = 0.063). Conclusions: Perioperative use of NSAIDs was associated with a reduced risk of cancer recurrence after resection for colorectal cancer. No effect on 5-year mortality or DFS was found.
- OSTI ID:
- 22927541
- Journal Information:
- Annals of Surgical Oncology (Online), Journal Name: Annals of Surgical Oncology (Online) Journal Issue: 12 Vol. 26; ISSN 1534-4681
- Country of Publication:
- United States
- Language:
- English
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