Antimicrobial Mechanism of Hydroquinone

Journal Article · Sun Dec 15 04:00:00 EST 2019 · Applied Biochemistry and Biotechnology

DOI:https://doi.org/10.1007/S12010-019-03067-1· OSTI ID:22927456

Ma, Changyang ^[1]; He, Nan; Zhao, Yingying; Xia, Dandan ^[2]; Wei, Jinfeng; Kang, Wenyi ^[1]

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1. Henan University, National R&D Center for Edible Fungus Processing Technology (China)
2. Henan University, Kaifeng Key Laboratory of Functional Components in Health Food (China)

With growing concern about the possible risks and side effects of antibiotic drugs, more and more natural products with antibacterial activity are studied as the substitutes. In this paper, the antibacterial activity of hydroquinone and arbutin in Ainsliaea bonatii was investigated, which both displayed relatively strong antibacterial activity against Staphylococcus aureus (SA), methicillin-resistant S. aureus (MRSA), and extended spectrum β-lactamase S. aureus (ESBL-SA). The antibacterial mechanism of hydroquinone had been explored by scanning electron microscopy (SEM), alkaline phosphatase (AKP), and bacterial extracellular protein leakage. Results showed that hydroquinone could destroy the bacterial cell wall and membrane, increase permeability, lead leakage of intracellular substance affect synthesis of protein, and influence expression of genes.

• OSTI ID: 22927456
• Journal Information: Applied Biochemistry and Biotechnology, Journal Name: Applied Biochemistry and Biotechnology Journal Issue: 4 Vol. 189; ISSN ABIBDL; ISSN 0273-2289
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ALKALINE PHOSPHATASE
ANTIBIOTICS
CELL WALL
MEMBRANES
PERMEABILITY
SCANNING ELECTRON MICROSCOPY
SIDE EFFECTS
STAPHYLOCOCCUS
SYNTHESIS