Advanced urothelial cancer: a radiology update
- Harvard Medical School, Department of Imaging, Dana Farber Cancer Institute (United States)
- Harvard Medical School, Lank Center for Genitourinary Oncology, Dana Farber Cancer Institute (United States)
- Harvard Medical School, Department of Radiology, Brigham and Women’s Hospital (United States)
The recent genomic characterization of urothelial carcinoma by the Cancer Genome Atlas Project, made possible by the introduction of high throughput, reduced cost, and sequence analysis, has shed new insights on the biology of advanced disease. In addition, studies on imaging of advanced urothelial carcinoma have widened the knowledge on disease presentation and on pattern of metastatic spread and their correlation with the underlying biology of urothelial carcinoma. The wide range of treatments for advanced urothelial cancer, including combined chemotherapy regimens and immune checkpoint inhibitors, each result in treatment class-specific patterns of response and adverse events. Results of studies point to the need for a reliable biomarker, perhaps with imaging, that predicts prognosis and treatment response to systemic treatment, and can be used to select the most effective treatment while minimizing toxicity. This review of advanced urothelial cancer introduces the latest advances in genetic profiling, the current role of imaging, the radiographic appearance of treatment response and their toxicities, and details potential future areas of imaging research.
- OSTI ID:
- 22925008
- Journal Information:
- Abdominal Radiology (Online), Journal Name: Abdominal Radiology (Online) Journal Issue: 12 Vol. 44; ISSN 2366-0058
- Country of Publication:
- United States
- Language:
- English
Similar Records
Mechanistic Insights into the Successful Development of Combination Therapy of Enfortumab Vedotin and Pembrolizumab for the Treatment of Locally Advanced or Metastatic Urothelial Cancer
Clinical significance of soluble forms of immune checkpoint molecules in advanced esophageal cancer