Magnetic resonance imaging findings of renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion in adults: a pilot study

Journal Article · Tue Jan 15 04:00:00 EST 2019 · Abdominal Radiology (Online)

DOI:https://doi.org/10.1007/S00261-018-1703-0· OSTI ID:22923172

Dai, Chenchen; Sheng, Ruofan; Ding, Yuqin ^[1]; Yang, Minglei ^[2]; Hou, Jun ^[3]; Zhou, Jianjun ^[1]

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1. Fudan University, Department of Radiology, Zhongshan Hospital (China)
2. Siemems Healthineers (China)
3. Fudan University, Department of Pathology, Zhongshan Hospital (China)

Purpose: The purpose of the study was to retrospectively analyze MRI findings of renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion (Xp11.2/TFE RCC) in adults. Methods: Sixteen patients with Xp11.2/TFE RCC were reviewed retrospectively. The clinical characteristics and imaging features were assessed and then compared between metastatic and non-metastatic subgroups. Results: The mean age at diagnosis was 47.4 (20–76) years. Seven (44 %) patients were men, and nine (56 %) patients were women. The lesions predominantly exhibited an endophytic distribution (n = 14, 88 %) with a capsule (n = 16, 100 %), accompanied by solid and cystic patterns (n = 12, 75%) and hemorrhage (n = 11, 69 %). The tumors prevalently appeared hyper- to isointense on T1WI (n = 14, 88 %), hypointense on T2WI (n = 13, 81 %), and hyperintense on DWI (n = 16, 100 %) with a lower ADC (P < 0.001) than that of the surrounding tissue. The tumors were less enhanced than the normal renal cortex in all phases with a prolonged enhancement pattern (P ≤ 0.001). In addition, six patients (38 %) developed recurrence or metastases. The RCCs with metastases showed an irregular shape (P = 0.013), an incomplete capsule (P = 0.018), heterogeneous solid-cystic patterns (P = 0.034), and hemorrhage (P = 0.037) than non-metastatic subgroups. Conclusions: MRI provides valuable information for the diagnosis of adult Xp11.2/TFE RCCs. Features including irregular shape, incomplete capsule, mixed solid-cystic pattern, and hemorrhage may indicate the occurrence of recurrence or metastases.

• OSTI ID: 22923172
• Journal Information: Abdominal Radiology (Online), Journal Name: Abdominal Radiology (Online) Journal Issue: 1 Vol. 44; ISSN 2366-0058
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ADULTS
CAPSULES
CARCINOMAS
DIAGNOSIS
HEMORRHAGE
KIDNEYS
MAGNETIC RESONANCE
METASTASES
NMR IMAGING
PATIENTS