Relationship between KRAS mutations and dual time point {sup 18}F-FDG PET/CT imaging in colorectal liver metastases

Journal Article · Sat Jun 15 04:00:00 EDT 2019 · Abdominal Radiology (Online)

DOI:https://doi.org/10.1007/S00261-018-1740-8· OSTI ID:22923005

Mao, Wujian; Zhou, Jun; Zhang, He; Qiu, Lin; Tan, Hui; Hu, Yan; Shi, Hongcheng ^[1]

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1. Shanghai Institute of Medical Imaging (China)

Purpose: To investigate the association between metabolic parameters of dual time point {sup 18}F-FDG PET/CT imaging and Kirsten rat sarcoma (KRAS) mutation status in colorectal liver metastases (CRLM). Methods: Forty-nine colorectal cancer patients with 87 liver metastatic lesions were included in this retrospective study. KRAS gene mutation tests were also performed for all the patients. The maximum standardized uptake value (SUV{sub max}) was measured for each hepatic metastatic lesion on both early and delayed scans, and the change of SUV{sub max} (ΔSUV{sub max}) and retention index (RI) were calculated. Uni-variate and multi-variate analyses were employed to determine the relationship between any PET/CT parameters and KRAS mutation status. Results: Thirty-seven (42.5%) liver metastatic lesions harboring KRAS mutations were identified. The SUV{sub max} of CRLM with KRAS mutation both on early and delayed scans was significantly higher than those with wild-type KRAS (10.7 ± 6.0 vs. 7.8 ± 3.3, P = 0.002; 15.5 ± 10.1 vs. 10.0 ± 4.2, P < 0.001, respectively). Compared with wild-type KRAS CRLM, ΔSUV{sub max} and RI (%) of CRLM with KRAS mutation were also significantly higher than those with wild-type KRAS (4.8 ± 4.7 vs. 2.2 ± 2.0, P < 0.001; 45.3 ± 28.2 vs. 29.6 ± 24.7, P = 0.003, respectively). Multi-variate analyses showed that the SUV{sub max} on both early and delayed scans, ΔSUV{sub max}, and RI (%) were the 4 independent factors to predict CRLM patients harboring KRAS mutations. Conclusion: The SUV{sub max} on both early and delayed scans, ΔSUV{sub max}, and RI (%) may be the 4 independent factors to predict CRLM patients harboring KRAS mutations.

• OSTI ID: 22923005
• Journal Information: Abdominal Radiology (Online), Journal Name: Abdominal Radiology (Online) Journal Issue: 6 Vol. 44; ISSN 2366-0058
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
FLUORINE 18
GENE MUTATIONS
LIVER
METASTASES
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
RATS
RETENTION
SARCOMAS
UPTAKE