Treatment-Related Noncontiguous Radiologic Changes in Children With Diffuse Intrinsic Pontine Glioma Treated With Expanded Irradiation Fields and Antiangiogenic Therapy

Journal Article · Thu Dec 14 23:00:00 EST 2017 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2017.08.021· OSTI ID:22901345

Patay, Zoltan ^[1]; Merchant, Thomas E. ^[2]; Nguyen, Rosa ^[3]; Pierson, Christopher R. ^[4]; Onar-Thomas, Arzu ^[5]; Broniscer, Alberto ^[3]

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1. Department of Diagnostic Imaging, St Jude Children's Research Hospital, Memphis (United States)
2. Department of Radiation Oncology, St Jude Children's Research Hospital, Memphis (United States)
3. Department of Oncology, St Jude Children's Research Hospital, Memphis (United States)
4. Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus (United States)
5. Department of Biostatistics, St Jude Children's Research Hospital, Memphis (United States)

We previously reported the cases of 3 children with diffuse intrinsic pontine glioma (DIPG) in whom noncontiguous treatment-related abnormalities (NCTRAs) developed in the brain after expanded-field radiation therapy (RT). To investigate the occurrence and putative mechanism of NCTRAs, we reviewed brain magnetic resonance imaging studies of patients with DIPG treated in 2 consecutive phase I clinical trials (trials 1 and 2).

• OSTI ID: 22901345
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 5 Vol. 99; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
CHILDREN
CLINICAL TRIALS
GLIOMAS
IRRADIATION
NMR IMAGING
PATIENTS
RADIOTHERAPY
REVIEWS