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Radiotherapy–immunotherapy combinations – perspectives and challenges
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March 2020 |
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Oxaliplatin regulates myeloid‐derived suppressor cell‐mediated immunosuppression via downregulation of nuclear factor‐κB signaling
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The expression of costimulatory molecules CD80 and CD86 in human carcinoma cell lines: its regulation by interferon γ and interleukin-10
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Inhibiting IDO pathways to treat cancer: lessons from the ECHO-301 trial and beyond
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Detection of Solid Tumor Molecular Residual Disease (MRD) Using Circulating Tumor DNA (ctDNA)
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High Prevalence of Activated Intraepithelial Cytotoxic T Lymphocytes and Increased Neoplastic Cell Apoptosis in Colorectal Carcinomas with Microsatellite Instability
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Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch & Wait Database (IWWD): an international multicentre registry study
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Effect of adding mFOLFOX6 after neoadjuvant chemoradiation in locally advanced rectal cancer: a multicentre, phase 2 trial
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Radiation and checkpoint blockade immunotherapy: radiosensitisation and potential mechanisms of synergy
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Watch-and-wait approach versus surgical resection after chemoradiotherapy for patients with rectal cancer (the OnCoRe project): a propensity-score matched cohort analysis
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Chemoimmunotherapy by combining oxaliplatin with immune checkpoint blockades reduced tumor burden in colorectal cancer animal model
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Low-Dose Irradiation Programs Macrophage Differentiation to an iNOS+/M1 Phenotype that Orchestrates Effective T Cell Immunotherapy
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Prognostic Value of the Microsatellite Instability Status in Patients With Stage II/III Rectal Cancer Following Upfront Surgery
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High versus low dose irradiation for tumor immune reprogramming
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Comparing outcomes following total neoadjuvant therapy and following neoadjuvant chemoradiation therapy in patients with locally advanced rectal cancer
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Radiation Enhances Regulatory T Cell Representation
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Local Recurrence After Complete Clinical Response and Watch and Wait in Rectal Cancer After Neoadjuvant Chemoradiation: Impact of Salvage Therapy on Local Disease Control
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Five Fractions of Radiation Therapy Followed by 4 Cycles of FOLFOX Chemotherapy as Preoperative Treatment for Rectal Cancer
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Chemoradiation-Induced Alteration of Programmed Death-Ligand 1 and CD8+ Tumor-Infiltrating Lymphocytes Identified Patients With Poor Prognosis in Rectal Cancer: A Matched Comparison Analysis
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A Prospective Trial of Non-Operative Radiation Management of Adenocarcinoma of the Lower Rectum (NORMAL-R): Interim Analysis
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Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability
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Hybrid Capture–Based Genomic Profiling of Circulating Tumor DNA from Patients with Advanced Non–Small Cell Lung Cancer
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Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer
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Microbiome in Colorectal Cancer: How to Get from Meta-omics to Mechanism?
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Therapeutic targeting of inflammation and tryptophan metabolism in colon and gastrointestinal cancer
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The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
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Integrated digital error suppression for improved detection of circulating tumor DNA
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DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity
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A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
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An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage
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Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy
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February 2005 |
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Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
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August 2007 |
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Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
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June 2002 |
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Breathing new life into immunotherapy: review of melanoma, lung and kidney cancer
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Radiation enteropathy—pathogenesis, treatment and prevention
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April 2014 |
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Immunogenic death of colon cancer cells treated with oxaliplatin
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Resistance to checkpoint blockade therapy through inactivation of antigen presentation
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Inflammatory microenvironment remodelling by tumour cells after radiotherapy
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March 2020 |
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Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli
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February 2020 |
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A rectal cancer organoid platform to study individual responses to chemoradiation
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October 2019 |
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Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers
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April 2020 |
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Association of mismatch repair status with survival and response to neoadjuvant chemo(radio)therapy in rectal cancer
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September 2020 |
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Circulating tumor DNA dynamics predict benefit from consolidation immunotherapy in locally advanced non-small-cell lung cancer
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January 2020 |
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A ‘modified de Gramont’ regimen of fluorouracil, alone and with oxaliplatin, for advanced colorectal cancer
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August 2002 |
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Calreticulin exposure is required for the immunogenicity of γ-irradiation and UVC light-induced apoptosis
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Regulation of Surface and Intracellular Expression of CTLA‐4 on Human Peripheral T Cells
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IDO1 Metabolites Activate β-catenin Signaling to Promote Cancer Cell Proliferation and Colon Tumorigenesis in Mice
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Probiotic Gut Bacteria Enhance Cancer Immunotherapy in a Mouse Model of Melanoma
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July 2016 |
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Oxaliplatin, Fluorouracil, and Leucovorin as Adjuvant Treatment for Colon Cancer
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June 2004 |
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Preoperative versus Postoperative Chemoradiotherapy for Rectal Cancer
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PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
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June 2015 |
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Durvalumab after Chemoradiotherapy in Stage III Non–Small-Cell Lung Cancer
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November 2017 |
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Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC
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December 2018 |
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Novel Signal Transduction Pathway Utilized by Extracellular HSP70
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April 2002 |
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Health-related quality of life in rectal cancer patients undergoing neoadjuvant chemoradiation with delayed surgery versus short-course radiotherapy with immediate surgery: a propensity score-matched cohort study
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Type-I-interferons in infection and cancer: Unanticipated dynamics with therapeutic implications
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May 2017 |
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PD-1/PD-L1 pathway: an adaptive immune resistance mechanism to immunogenic chemotherapy in colorectal cancer
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February 2018 |
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Potential immune priming of the tumor microenvironment with FOLFOX chemotherapy in locally advanced rectal cancer
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February 2018 |
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Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy
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Type I interferon is selectively required by dendritic cells for immune rejection of tumors
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Chemoradiation, surgery and adjuvant chemotherapy versus induction chemotherapy followed by chemoradiation and surgery: long-term results of the Spanish GCR-3 phase II randomized trial
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Long-course preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for clinical T4 and fixed clinical T3 rectal cancer: long-term results of the randomized Polish II study
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Cancer Immunotherapy with Anti-CTLA-4 Monoclonal Antibodies Induces an Inflammatory Bowel Disease
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Long-term Outcome of an Organ Preservation Program After Neoadjuvant Treatment for Rectal Cancer
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Effect of preoperative chemoradiotherapy on the immunological status of rectal cancer patients
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July 2020 |
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Operative Versus Nonoperative Treatment for Stage 0 Distal Rectal Cancer Following Chemoradiation Therapy
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October 2004 |
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Anti-PD1-induced collagenous colitis in a melanoma patient
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Consolidation mFOLFOX6 Chemotherapy After Chemoradiotherapy Improves Survival in Patients With Locally Advanced Rectal Cancer: Final Results of a Multicenter Phase II Trial
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Microsatellite Instability (MSI) as an Independent Predictor of Pathologic Complete Response (PCR) in Locally Advanced Rectal Cancer
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April 2020 |
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Patient-Reported Outcomes After Neoadjuvant Chemoradiotherapy for Rectal Cancer
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Nonoperative Management of Rectal Cancer With Complete Clinical Response After Neoadjuvant Therapy
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Prophylactic probiotics for cancer therapy-induced diarrhoea: a meta-analysis
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June 2018 |
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Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
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Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy
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Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
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November 2015 |
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Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria
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February 2018 |
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Up-Regulation of PD-L1, IDO, and T regs in the Melanoma Tumor Microenvironment Is Driven by CD8 + T Cells
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August 2013 |
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Lactobacillus probiotic protects intestinal epithelium from radiation injury in a TLR-2/cyclo-oxygenase-2-dependent manner
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Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: a prospective biomarker study
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Lactobacillus rhamnosusGG protects the intestinal epithelium from radiation injury through release of lipoteichoic acid, macrophage activation and the migration of mesenchymal stem cells
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June 2018 |
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Tumor Cell Death and ATP Release Prime Dendritic Cells and Efficient Anticancer Immunity
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The Efficacy of Radiotherapy Relies upon Induction of Type I Interferon–Dependent Innate and Adaptive Immunity
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Adverse Immunoregulatory Effects of 5FU and CPT11 Chemotherapy on Myeloid-Derived Suppressor Cells and Colorectal Cancer Outcomes
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Acquired Resistance to Fractionated Radiotherapy Can Be Overcome by Concurrent PD-L1 Blockade
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IDO1 and Kynurenine Pathway Metabolites Activate PI3K-Akt Signaling in the Neoplastic Colon Epithelium to Promote Cancer Cell Proliferation and Inhibit Apoptosis
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Ablative Tumor Radiation Can Change the Tumor Immune Cell Microenvironment to Induce Durable Complete Remissions
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Blocking Indolamine-2,3-Dioxygenase Rebound Immune Suppression Boosts Antitumor Effects of Radio-Immunotherapy in Murine Models and Spontaneous Canine Malignancies
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The Immune-microenvironment Confers Chemoresistance of Colorectal Cancer through Macrophage-Derived IL6
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Mismatch Repair–Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy
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Early Detection of Molecular Residual Disease in Localized Lung Cancer by Circulating Tumor DNA Profiling
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Genetic Mechanisms of Immune Evasion in Colorectal Cancer
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Interferon-Induced IDO1 Mediates Radiation Resistance and Is a Therapeutic Target in Colorectal Cancer
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February 1994 |
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Neoadjuvant Modified FOLFOX6 With or Without Radiation Versus Fluorouracil Plus Radiation for Locally Advanced Rectal Cancer: Final Results of the Chinese FOWARC Trial
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Clinical Relevance of Microsatellite Instability in Colorectal Cancer
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Capecitabine Plus Oxaliplatin Compared With Fluorouracil and Folinic Acid As Adjuvant Therapy for Stage III Colon Cancer
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Capecitabine and Oxaliplatin in the Preoperative Multimodality Treatment of Rectal Cancer: Surgical End Points From National Surgical Adjuvant Breast and Bowel Project Trial R-04
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Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair–Deficient/Microsatellite Instability–High Metastatic Colorectal Cancer
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Pembrolizumab versus chemotherapy for microsatellite instability-high/mismatch repair deficient metastatic colorectal cancer: The phase 3 KEYNOTE-177 Study.
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CD8+ and FOXP3+ Tumor-Infiltrating T Cells Before and After Chemoradiotherapy for Rectal Cancer
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Predictors of Bowel Function in Long-term Rectal Cancer Survivors with Anastomosis
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Somatic Mutation Profiles of MSI and MSS Colorectal Cancer Identified by Whole Exome Next Generation Sequencing and Bioinformatics Analysis
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Gamma-Ray Resistance of Regulatory CD4+CD25+Foxp3+T Cells in Mice
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A comprehensive longitudinal overview of health-related quality of life and symptoms after treatment for rectal cancer in the TME trial
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FOLFOX Chemotherapy Ameliorates CD8 T Lymphocyte Exhaustion and Enhances Checkpoint Blockade Efficacy in Colorectal Cancer
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The Determination of Immunomodulation and Its Impact on Survival of Rectal Cancer Patients Depends on the Area Comprising a Tissue Microarray
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Immunotherapy in colorectal cancer: Available clinical evidence, challenges and novel approaches
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Elevated TGF-β1 Secretion and Down-Modulation of NKG2D Underlies Impaired NK Cytotoxicity in Cancer Patients
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Radiation-Induced IFN-γ Production within the Tumor Microenvironment Influences Antitumor Immunity
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