Inhibition of glycolytic activator PFKFB3 suppresses tumor growth and induces tumor vessel normalization in hepatocellular carcinoma

Matsumoto, Kenichi; Noda, Takehiro; Kobayashi, Shogo; Sakano, Yoshihiro; Yokota, Yuki; Iwagami, Yoshifumi; Yamada, Daisaku; Tomimaru, Yoshito; Akita, Hirofumi; Gotoh, Kunihito; Takeda, Yutaka; Tanemura, Masahiro; Umeshita, Koji; Doki, Yuichiro; Eguchi, Hidetoshi

doi:10.1016/j.canlet.2020.12.011

Inhibition of glycolytic activator PFKFB3 suppresses tumor growth and induces tumor vessel normalization in hepatocellular carcinoma

Journal Article · Mon Mar 01 00:00:00 EST 2021 · Cancer Letters

DOI:https://doi.org/10.1016/j.canlet.2020.12.011· OSTI ID:2279309

; Noda, Takehiro; ; Sakano, Yoshihiro; Yokota, Yuki; Iwagami, Yoshifumi; Yamada, Daisaku; Tomimaru, Yoshito; Akita, Hirofumi; Gotoh, Kunihito; Takeda, Yutaka; Tanemura, Masahiro; Umeshita, Koji; Doki, Yuichiro; Eguchi, Hidetoshi

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View Accepted Manuscript (Publisher)

Sponsoring Organization:: USDOE

OSTI ID:: 2279309

Journal Information:: Cancer Letters, Journal Name: Cancer Letters Journal Issue: C Vol. 500; ISSN 0304-3835

Publisher:: ElsevierCopyright Statement

Country of Publication:: Netherlands

Language:: English

References (39)

Gastroenterological surgery in Japan: The past, the present and the future Colvin, Hugh; Mizushima, Tsunekazu; Eguchi, Hidetoshi Annals of Gastroenterological Surgery, Vol. 1, Issue 1 https://doi.org/10.1002/ags3.12008	journal	April 2017
By inhibiting PFKFB3, aspirin overcomes sorafenib resistance in hepatocellular carcinoma Li, Sainan; Dai, Weiqi; Mo, Wenhui International Journal of Cancer, Vol. 141, Issue 12 https://doi.org/10.1002/ijc.31022	journal	September 2017
Inhibition of E-selectin expression on the surface of endothelial cells inhibits hepatocellular carcinoma growth by preventing tumor angiogenesis Borentain, Patrick; Carmona, Sylvie; Mathieu, Sylvie Cancer Chemotherapy and Pharmacology, Vol. 77, Issue 4 https://doi.org/10.1007/s00280-016-3006-x	journal	March 2016
Use of labeled tomato lectin for imaging vasculature structures Robertson, Richard T.; Levine, Samantha T.; Haynes, Sherry M. Histochemistry and Cell Biology, Vol. 143, Issue 2 https://doi.org/10.1007/s00418-014-1301-3	journal	December 2014
Inhibition of 6-phosphofructo-2-kinase (PFKFB3) suppresses glucose metabolism and the growth of HER2+ breast cancer O’Neal, Julie; Clem, Amy; Reynolds, Lindsey Breast Cancer Research and Treatment, Vol. 160, Issue 1 https://doi.org/10.1007/s10549-016-3968-8	journal	September 2016
Antiangiogenic therapy in oncology: current status and future directions Jayson, Gordon C.; Kerbel, Robert; Ellis, Lee M. The Lancet, Vol. 388, Issue 10043 https://doi.org/10.1016/S0140-6736(15)01088-0	journal	July 2016
The synergistic effect of PFK15 with metformin exerts anti-myeloma activity via PFKFB3 Liu, Xinling; Zhao, Yi; Zhang, Enfan Biochemical and Biophysical Research Communications, Vol. 515, Issue 2 https://doi.org/10.1016/j.bbrc.2019.05.136	journal	July 2019
Human esophageal cancer endothelial cells increase tumor growth by incorporating with mouse endothelium Hu, Hai; Zhang, Yushan; Ran, Yuling Cancer Letters, Vol. 252, Issue 1 https://doi.org/10.1016/j.canlet.2006.12.015	journal	July 2007
Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia Jain, Rakesh K. Cancer Cell, Vol. 26, Issue 5 https://doi.org/10.1016/j.ccell.2014.10.006	journal	November 2014
Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy Cantelmo, Anna Rita; Conradi, Lena-Christin; Brajic, Aleksandra Cancer Cell, Vol. 30, Issue 6 https://doi.org/10.1016/j.ccell.2016.10.006	journal	December 2016
Angiocrine Factors Deployed by Tumor Vascular Niche Induce B Cell Lymphoma Invasiveness and Chemoresistance Cao, Zhongwei; Ding, Bi-Sen; Guo, Peipei Cancer Cell, Vol. 25, Issue 3 https://doi.org/10.1016/j.ccr.2014.02.005	journal	March 2014
Partial and Transient Reduction of Glycolysis by PFKFB3 Blockade Reduces Pathological Angiogenesis Schoors, Sandra; De Bock, Katrien; Cantelmo, Anna Rita Cell Metabolism, Vol. 19, Issue 1 https://doi.org/10.1016/j.cmet.2013.11.008	journal	January 2014
Targeting PFKFB3 in the Endothelium for Cancer Therapy Yang, Qi; Hou, Peng Trends in Molecular Medicine, Vol. 23, Issue 3 https://doi.org/10.1016/j.molmed.2017.01.008	journal	March 2017
Role of miRNAs in tumor and endothelial cell interactions during tumor progression Orso, Francesca; Quirico, Lorena; Dettori, Daniela Seminars in Cancer Biology, Vol. 60 https://doi.org/10.1016/j.semcancer.2019.07.024	journal	February 2020
Endothelial Cell Metabolism in Health and Disease Rohlenova, Katerina; Veys, Koen; Miranda-Santos, Ines Trends in Cell Biology, Vol. 28, Issue 3 https://doi.org/10.1016/j.tcb.2017.10.010	journal	March 2018
Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics Kanda, Y. Bone Marrow Transplantation, Vol. 48, Issue 3 https://doi.org/10.1038/bmt.2012.244	journal	December 2012
Glycolytic regulation of cell rearrangement in angiogenesis Cruys, Bert; Wong, Brian W.; Kuchnio, Anna Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms12240	journal	July 2016
Isolation of endothelial cells from fresh tissues van Beijnum, Judy R.; Rousch, Mat; Castermans, Karolien Nature Protocols, Vol. 3, Issue 6 https://doi.org/10.1038/nprot.2008.71	journal	June 2008
Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors Butler, Jason M.; Kobayashi, Hideki; Rafii, Shahin Nature Reviews Cancer, Vol. 10, Issue 2 https://doi.org/10.1038/nrc2791	journal	February 2010
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases Carmeliet, Peter; Jain, Rakesh K. Nature Reviews Drug Discovery, Vol. 10, Issue 6 https://doi.org/10.1038/nrd3455	journal	June 2011
PFKFB3 blockade inhibits hepatocellular carcinoma growth by impairing DNA repair through AKT Shi, Wen-Kai; Zhu, Xiao-Dong; Wang, Cheng-Hao Cell Death & Disease, Vol. 9, Issue 4 https://doi.org/10.1038/s41419-018-0435-y	journal	March 2018
Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan Maishi, Nako; Ohba, Yusuke; Akiyama, Kosuke Scientific Reports, Vol. 6, Issue 1 https://doi.org/10.1038/srep28039	journal	June 2016
Endothelial cell metabolism: an update anno 2017 Teuwen, Laure-Anne; Draoui, Nihed; Dubois, Charlotte Current Opinion in Hematology, Vol. 24, Issue 3 https://doi.org/10.1097/MOH.0000000000000335	journal	May 2017
The Feasibility of Third or More Repeat Hepatectomy for Recurrent Hepatocellular Carcinoma Mise, Yoshihiro; Hasegawa, Kiyoshi; Shindoh, Junichi Annals of Surgery, Vol. 262, Issue 2 https://doi.org/10.1097/SLA.0000000000000882	journal	August 2015
Angiogenesis revisited from a metabolic perspective: role and therapeutic implications of endothelial cell metabolism Draoui, Nihed; de Zeeuw, Pauline; Carmeliet, Peter Open Biology, Vol. 7, Issue 12 https://doi.org/10.1098/rsob.170219	journal	December 2017
Tumor endothelial cells accelerate tumor metastasis Maishi, Nako; Hida, Kyoko Cancer Science, Vol. 108, Issue 10 https://doi.org/10.1111/cas.13336	journal	August 2017
Role of histone deacetylase 1 in distant metastasis of pancreatic ductal cancer Shinke, Go; Yamada, Daisaku; Eguchi, Hidetoshi Cancer Science, Vol. 109, Issue 8 https://doi.org/10.1111/cas.13700	journal	July 2018
PLOD2 induced under hypoxia is a novel prognostic factor for hepatocellular carcinoma after curative resection Noda, Takehiro; Yamamoto, Hirofumi; Takemasa, Ichiro Liver International, Vol. 32, Issue 1 https://doi.org/10.1111/j.1478-3231.2011.02619.x	journal	August 2011
Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy Jain, R. K. Science, Vol. 307, Issue 5706 https://doi.org/10.1126/science.1104819	journal	January 2005
Genes Expressed in Human Tumor Endothelium Croix, Brad St.; Rago, Carlo; Velculescu, Victor Science, Vol. 289, Issue 5482 https://doi.org/10.1126/science.289.5482.1197	journal	August 2000
Phosphorylation of the 6-Phosphofructo-2-Kinase/Fructose 2,6-Bisphosphatase/PFKFB3 Family of Glycolytic Regulators in Human Cancer Bando, Hidenori; Atsumi, Toshiya; Nishio, Taro Clinical Cancer Research, Vol. 11, Issue 16 https://doi.org/10.1158/1078-0432.CCR-05-0149	journal	August 2005
Targeting 6-Phosphofructo-2-Kinase (PFKFB3) as a Therapeutic Strategy against Cancer Clem, Brian F.; O'Neal, Julie; Tapolsky, Gilles Molecular Cancer Therapeutics, Vol. 12, Issue 8 https://doi.org/10.1158/1535-7163.MCT-13-0097	journal	August 2013
Endothelial Alpha-Parvin Controls Integrity of Developing Vasculature and Is Required for Maintenance of Cell–Cell Junctions Fraccaroli, Alessia; Pitter, Bettina; Taha, Abdallah Abu Circulation Research, Vol. 117, Issue 1 https://doi.org/10.1161/CIRCRESAHA.117.305818	journal	June 2015
Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma Li, Hui-Min; Yang, Jie-Gang; Liu, Zhuo-Jue Journal of Experimental & Clinical Cancer Research, Vol. 36, Issue 1 https://doi.org/10.1186/s13046-016-0481-1	journal	January 2017
The role of microenvironment in tumor angiogenesis Jiang, Xianjie; Wang, Jie; Deng, Xiangying Journal of Experimental & Clinical Cancer Research, Vol. 39, Issue 1 https://doi.org/10.1186/s13046-020-01709-5	journal	September 2020
Role of the Hypoxia-Related Gene, JMJD1A, in Hepatocellular Carcinoma: Clinical Impact on Recurrence after Hepatic Resection Yamada, Daisaku; Kobayashi, Shogo; Yamamoto, Hirofumi Annals of Surgical Oncology, Vol. 19, Issue S3 https://doi.org/10.1245/s10434-011-1797-x	journal	May 2011
PFK15, a Small Molecule Inhibitor of PFKFB3, Induces Cell Cycle Arrest, Apoptosis and Inhibits Invasion in Gastric Cancer Zhu, Wei; Ye, Liang; Zhang, Jianzhao PLOS ONE, Vol. 11, Issue 9 https://doi.org/10.1371/journal.pone.0163768	journal	September 2016
Global cancer statistics, 2012: Global Cancer Statistics, 2012 Torre, Lindsey A.; Bray, Freddie; Siegel, Rebecca L. CA: A Cancer Journal for Clinicians, Vol. 65, Issue 2 https://doi.org/10.3322/caac.21262	journal	February 2015
The Warburg Effect in Endothelial Cells and its Potential as an Anti-angiogenic Target in Cancer Fitzgerald, Gillian; Soro-Arnaiz, Inés; De Bock, Katrien Frontiers in Cell and Developmental Biology, Vol. 6 https://doi.org/10.3389/fcell.2018.00100	journal	September 2018

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