Nanosized Particles of Tantalum, Hafnium, and Cerium Oxides Used with Monochromatic Photon Beams and Brachytherapy Sources

Journal Article · Sun Jul 15 04:00:00 EDT 2018 · Optics and Spectroscopy

DOI:https://doi.org/10.1134/S0030400X18070196· OSTI ID:22786332

Belousov, A. V. ^[1]; Krusanov, G. A. ^[2]; Kolyvanova, M. A. ^[3]; Krivoshapkin, P. V.; Vinogradov, V. V. ^[4]; Chernyaev, A. P. ^[1]; Shtil, A. A. ^[4]

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1. Moscow State University, Department of Physics (Russian Federation)
2. Moscow State University, Skobeltsyn Institute of Nuclear Physics (Russian Federation)
3. Burnazyan Federal Medical Biophysical Center (Russian Federation)
4. ITMO University (Russian Federation)

High-Z nanoparticles can increase the absorbed radiation dose if they are accumulated in tumor cells. The quantitative measure of this radiosensitization effect is the dose enhancement factor (DEF), that is, the ratio of the doses absorbed in the presence and in the absence of nanoparticles. In the present work, the values of the dose enhancement factors of Ta{sub 2}O{sub 5}, HfO{sub 2}, and CeO{sub 2} ceramic nanoparticles were calculated analytically for monochromatic radiation of the X-ray energy range (1–180 keV) and for low-energy sources for brachytherapy: {sup 103}Pd (mean energy, 20.6 keV), {sup 125}I (26.7 keV), and {sup 131}Cs (30.4 keV). For all types of nanoparticles in the concentration of 5 mg/mL, the values of the dose enhancement factor were high both for monochromatic radiation and for brachytherapy sources. The highest DEF values of ~1.7 were obtained for nanoparticles of tantalum oxide. For brachytherapy sources, the highest dose enhancement factors (1.48 to 1.67) were obtained for Ta{sub 2}O{sub 5} and HfO{sub 2} nanoparticles. These results confirm that ceramic nanoparticles are promising dose modifying agents for radiotherapy.

• OSTI ID: 22786332
• Journal Information: Optics and Spectroscopy, Journal Name: Optics and Spectroscopy Journal Issue: 1 Vol. 125; ISSN 0030-400X; ISSN OPSUA3
• Country of Publication: United States
• Language: English

Related Subjects

07 ISOTOPE AND RADIATION SOURCES
77 NANOSCIENCE AND NANOTECHNOLOGY
ABSORBED RADIATION DOSES
BRACHYTHERAPY
CERAMICS
CERIUM OXIDES
CESIUM 131
CONCENTRATION RATIO
ENERGY SOURCES
HAFNIUM OXIDES
IODINE 125
KEV RANGE 10-100
MONOCHROMATIC RADIATION
NANOPARTICLES
NANOSTRUCTURES
PALLADIUM 103
PHOTON BEAMS
TANTALUM OXIDES
TUMOR CELLS
X RADIATION