SPION@APTES@FA-PEG@Usnic Acid Bionanodrug for Cancer Therapy

Journal Article · Tue May 15 00:00:00 EDT 2018 · Journal of Superconductivity and Novel Magnetism

DOI:https://doi.org/10.1007/S10948-017-4333-9· OSTI ID:22771329

Alpsoy, L. ^[1]; Amir, Md. ^[2]; Ülker, Z. ^[1]; Nawaz, M. ^[3]

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1. Gama Mechatronics Company (Turkey)
2. Istanbul University, Faculty of Engineering, Department of Chemistry (Turkey)
3. University of Dammam, Department of Nano-Medicine Research, Institute for Research and Medical Consultations (IRMC) (Saudi Arabia)

In this work, we aimed to develop stable usnic acid (UA)-conjugated superparamagnetic iron oxide nanoparticles (SPIONs) as a potential drug carrier for in vitro analysis of MCF-7 (breast cancer cell line), HeLa (cervix cancer cell line), L929 (mouse fibroblast cell line), U87 (glioblastoma cell line, brain cancer), and A549 (human lung cancer cell line) cell lines. SPIONs were synthesized via the polyol method and functionalized with APTES using the Stöber method. Carboxylated polyethylene glycol (PEG-COOH), folic acid (FA), and carboxylated luteolin (CL) were conjugated on the surface via a carboxylic/amine group using the nanoprecipitation method, respectively. X-ray powder diffraction analysis confirmed the purity of the product with crystallite size of around 11 nm. Fourier-transformed infrared spectrophotometer (FT-IR) analyses explained the conjugation of all functional groups to the surface of SPIONs. The percentages of inorganic and organic content in the products were investigated via thermal gravimetric analyzer (TGA). For morphological analysis, a transmission electron microscope (TEM) was used. The superparamagnetic property of the product was also confirmed by vibrating sample magnetometer (VSM).

• OSTI ID: 22771329
• Journal Information: Journal of Superconductivity and Novel Magnetism, Vol. 31, Issue 5; Other Information: Copyright (c) 2018 Springer Science+Business Media, LLC, part of Springer Nature; Article Copyright (c) 2017 Springer Science+Business Media, LLC; http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); ISSN 1557-1939
• Country of Publication: United States
• Language: English

Related Subjects

75 CONDENSED MATTER PHYSICS
SUPERCONDUCTIVITY AND SUPERFLUIDITY
60 APPLIED LIFE SCIENCES
DRUG DELIVERY
FIBROBLASTS
FOLIC ACID
FOURIER TRANSFORM SPECTROMETERS
IN VITRO
IRON OXIDES
MAGNETIC PROPERTIES
MAMMARY GLANDS
NANOPARTICLES
POLYETHYLENE GLYCOLS
SPECTROPHOTOMETERS
SUPERPARAMAGNETISM
THERAPY
THERMAL GRAVIMETRIC ANALYSIS
TRANSMISSION ELECTRON MICROSCOPY
VIBRATING SAMPLE MAGNETOMETERS
X-RAY DIFFRACTION