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Title: SPION@APTES@FA-PEG@Usnic Acid Bionanodrug for Cancer Therapy

Abstract

In this work, we aimed to develop stable usnic acid (UA)-conjugated superparamagnetic iron oxide nanoparticles (SPIONs) as a potential drug carrier for in vitro analysis of MCF-7 (breast cancer cell line), HeLa (cervix cancer cell line), L929 (mouse fibroblast cell line), U87 (glioblastoma cell line, brain cancer), and A549 (human lung cancer cell line) cell lines. SPIONs were synthesized via the polyol method and functionalized with APTES using the Stöber method. Carboxylated polyethylene glycol (PEG-COOH), folic acid (FA), and carboxylated luteolin (CL) were conjugated on the surface via a carboxylic/amine group using the nanoprecipitation method, respectively. X-ray powder diffraction analysis confirmed the purity of the product with crystallite size of around 11 nm. Fourier-transformed infrared spectrophotometer (FT-IR) analyses explained the conjugation of all functional groups to the surface of SPIONs. The percentages of inorganic and organic content in the products were investigated via thermal gravimetric analyzer (TGA). For morphological analysis, a transmission electron microscope (TEM) was used. The superparamagnetic property of the product was also confirmed by vibrating sample magnetometer (VSM).

Authors:
 [1];  [2];  [3];  [1];  [2]
  1. Gama Mechatronics Company (Turkey)
  2. University of Dammam, Department of Nano-Medicine Research, Institute for Research and Medical Consultations (IRMC) (Saudi Arabia)
  3. Istanbul University, Faculty of Engineering, Department of Chemistry (Turkey)
Publication Date:
OSTI Identifier:
22771329
Resource Type:
Journal Article
Journal Name:
Journal of Superconductivity and Novel Magnetism
Additional Journal Information:
Journal Volume: 31; Journal Issue: 5; Other Information: Copyright (c) 2018 Springer Science+Business Media, LLC, part of Springer Nature; Article Copyright (c) 2017 Springer Science+Business Media, LLC; http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 1557-1939
Country of Publication:
United States
Language:
English
Subject:
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; 60 APPLIED LIFE SCIENCES; DRUG DELIVERY; FIBROBLASTS; FOLIC ACID; FOURIER TRANSFORM SPECTROMETERS; IN VITRO; IRON OXIDES; MAGNETIC PROPERTIES; MAMMARY GLANDS; NANOPARTICLES; POLYETHYLENE GLYCOLS; SPECTROPHOTOMETERS; SUPERPARAMAGNETISM; THERAPY; THERMAL GRAVIMETRIC ANALYSIS; TRANSMISSION ELECTRON MICROSCOPY; VIBRATING SAMPLE MAGNETOMETERS; X-RAY DIFFRACTION

Citation Formats

Alpsoy, L., Baykal, A., E-mail: abaykal@uod.edu.sa, Amir, Md., Ülker, Z., and Nawaz, M. SPION@APTES@FA-PEG@Usnic Acid Bionanodrug for Cancer Therapy. United States: N. p., 2018. Web. doi:10.1007/S10948-017-4333-9.
Alpsoy, L., Baykal, A., E-mail: abaykal@uod.edu.sa, Amir, Md., Ülker, Z., & Nawaz, M. SPION@APTES@FA-PEG@Usnic Acid Bionanodrug for Cancer Therapy. United States. doi:10.1007/S10948-017-4333-9.
Alpsoy, L., Baykal, A., E-mail: abaykal@uod.edu.sa, Amir, Md., Ülker, Z., and Nawaz, M. Tue . "SPION@APTES@FA-PEG@Usnic Acid Bionanodrug for Cancer Therapy". United States. doi:10.1007/S10948-017-4333-9.
@article{osti_22771329,
title = {SPION@APTES@FA-PEG@Usnic Acid Bionanodrug for Cancer Therapy},
author = {Alpsoy, L. and Baykal, A., E-mail: abaykal@uod.edu.sa and Amir, Md. and Ülker, Z. and Nawaz, M.},
abstractNote = {In this work, we aimed to develop stable usnic acid (UA)-conjugated superparamagnetic iron oxide nanoparticles (SPIONs) as a potential drug carrier for in vitro analysis of MCF-7 (breast cancer cell line), HeLa (cervix cancer cell line), L929 (mouse fibroblast cell line), U87 (glioblastoma cell line, brain cancer), and A549 (human lung cancer cell line) cell lines. SPIONs were synthesized via the polyol method and functionalized with APTES using the Stöber method. Carboxylated polyethylene glycol (PEG-COOH), folic acid (FA), and carboxylated luteolin (CL) were conjugated on the surface via a carboxylic/amine group using the nanoprecipitation method, respectively. X-ray powder diffraction analysis confirmed the purity of the product with crystallite size of around 11 nm. Fourier-transformed infrared spectrophotometer (FT-IR) analyses explained the conjugation of all functional groups to the surface of SPIONs. The percentages of inorganic and organic content in the products were investigated via thermal gravimetric analyzer (TGA). For morphological analysis, a transmission electron microscope (TEM) was used. The superparamagnetic property of the product was also confirmed by vibrating sample magnetometer (VSM).},
doi = {10.1007/S10948-017-4333-9},
journal = {Journal of Superconductivity and Novel Magnetism},
issn = {1557-1939},
number = 5,
volume = 31,
place = {United States},
year = {2018},
month = {5}
}