Synthesis, Spectroscopy, and α-Glucosidase Inhibitory Activity of 3-Substituted Hydrazone Derivatives and Crystal Structure of (1E,2E)-1,2-Bis[1-(3-methoxyphenyl)ethylidene]hydrazone

Journal Article · Fri Dec 15 00:00:00 EST 2017 · Crystallography Reports

DOI:https://doi.org/10.1134/S1063774517070069· OSTI ID:22758299

Ruanwas, P. ^[1]; Sontimuang, C. ^[2]; Fun, H. -K. ^[3]

---

1. Prince of Songkla University, Department of Chemistry, Faculty of Science (Thailand)
2. Prince of Songkla University, Faculty of Traditional Thai Medicine (Thailand)
3. Universiti Sains Malaysia, X-ray Crystallography Unit, School of Physics (Thailand)

Six 3-substituted hydrazone derivatives [R = −OCH{sub 3} (1), −NH{sub 2} (2), −NO{sub 2} (3), −F (4), −Cl (5), and −Br (6)] were synthesized by condensation reaction. Their structures were elucidated by {sup 1}H NMR, FT-IR and UV-Vis spectroscopy. The synthesized compounds were further evaluated for their α-glucosidase inhibitory activity. Strong activity was found for 1 and 3. The crystal structure of 1 was determined by single crystal X-ray diffraction: a = 6.9743(1) Å, b = 18.3627(3) Å, c = 12.0207(2) Å, β = 96.087(1)o, sp. gr. P2{sub 1}/c, Z = 4. The molecule of 1 is twisted with the dihedral angle between the two phenyl rings being 51.91(4)°. In the crystal packing, the molecules are linked into chains by C–H···π interactions.

• OSTI ID: 22758299
• Journal Information: Crystallography Reports, Vol. 62, Issue 7; Other Information: Copyright (c) 2017 Pleiades Publishing, Inc.; Country of input: International Atomic Energy Agency (IAEA); ISSN 1063-7745
• Country of Publication: United States
• Language: English

Related Subjects

75 CONDENSED MATTER PHYSICS
SUPERCONDUCTIVITY AND SUPERFLUIDITY
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
CHAINS
CRYSTAL STRUCTURE
FOURIER TRANSFORM SPECTROMETERS
GLUCOSIDASE
HYDRAZONES
HYDROGEN 1
INFRARED SPECTRA
INTERACTIONS
MOLECULES
MONOCRYSTALS
NITROGEN DIOXIDE
NUCLEAR MAGNETIC RESONANCE
SPECTROSCOPY
SYNTHESIS
X-RAY DIFFRACTION