Synthesis, Crystal Structure, Electrochemical Properties, and Biological Activity of 2-((1H-Benzimidazol-2-yl)methylamino)acetic Acid

Journal Article · Sun Jul 15 04:00:00 UTC 2018 · Crystallography Reports

DOI:https://doi.org/10.1134/S1063774518040235· OSTI ID:22758217

Sabithakala, T. ^[1]; Bhargavi, G. ^[2]

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1. Jawaharlal Nehru Technological University Hyderabad, Department of Chemistry (India)
2. University of Hyderabad, School of Chemistry (India)

A water soluble compound, (2-((1H-benzimidazol-2-yl)methylamino)acetic acid, BIGH, has been synthesized and structurally characterized by elemental analysis, IR and UV spectroscopies, {sup 1}H-NMR, thermogravimetric and differential thermal analyses, and single crystal and powder X-ray diffraction. BIGH can act as a flexible planar ligand with three potential coordination sites. It crystallizes in a monoclinic system with the sp. gr. P2{sub 1}/c with the unit cell parameters, a = 9.3764(7) Å, b = 11.5031(8) Å, c = 10.0543(6) Å, and Z = 4. The crystal structure was stabilized through inter-molecular hydrogen bonds. The anti-microbial activity of the compound has been studied against Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, and Staphylococcus aureus, which showed a good activity against Bacillus subtilis. Cyclic voltammogram of the compound shows that it is a redox-active molecule.

• OSTI ID: 22758217
• Journal Information: Crystallography Reports, Journal Name: Crystallography Reports Journal Issue: 4 Vol. 63; ISSN CYSTE3; ISSN 1063-7745
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
60 APPLIED LIFE SCIENCES
ACETIC ACID
BACILLUS SUBTILIS
DIFFERENTIAL THERMAL ANALYSIS
ELECTROCHEMISTRY
ESCHERICHIA COLI
HYDROGEN
HYDROGEN 1
LIGANDS
MOLECULES
MONOCLINIC LATTICES
MONOCRYSTALS
NUCLEAR MAGNETIC RESONANCE
POWDERS
PSEUDOMONAS
SPECTROSCOPY
STAPHYLOCOCCUS
SYNTHESIS
THERMAL GRAVIMETRIC ANALYSIS
WATER
X-RAY DIFFRACTION