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Title: Cytokines and {sup 90}Y-Radioembolization: Relation to Liver Function and Overall Survival

Abstract

BackgroundTo evaluate the course of pro- and anti-inflammatory cytokines after {sup 90}Y-radioembolization (RE) of liver malignancies and to identify prognosticators for liver-related adverse events and survival.MethodsIn 34 consecutive patients with secondary or primary liver tumors scheduled for RE, the following cytokines were measured prior to and 2 h, 3 days, and 6 weeks after RE: interleukin (IL) -1, IL-2, IL-4, IL-6, IL-8, tumor necrosis factor alpha (TNF-α), and interferon-γ. Liver function impairment was defined as an elevation of liver-related laboratory values as graded by CTCAE ≥ 2 and/or serum bilirubin ≥30 µmol/l and/or development of ascites at 6-week follow-up.ResultsSignificant changes over time were seen in IL-1 (increase from 0.4 pg/ml (±0.7) at baseline to 1.1 pg/ml (±1.4) 3 days after RE (p = 0.02)), and in IL-6 (increase from 16.8 pg/ml (±21.8) at baseline to 54.6 pg/ml (±78.2) 3 days after RE (p = 0.003)). Baseline values of IL-6 and IL-8 were independently associated with liver function impairment at follow-up as well as decreased survival with an optimal cutoff at 6.53 and 60.8 pg/ml, respectively.ConclusionExpected changes in pro- and anti-inflammatory cytokines after RE were shown. Furthermore, baseline values of IL-6 and IL-8 were associated with later liver dysfunction and survival. We hypothesize that these biomarkers are potential prognosticators and might help in patient selection for RE.

Authors:
; ; ; ;  [1];  [2]; ; ; ;  [1]
  1. Universitätsklinik Magdeburg, Klinik für Radiologie und Nuklearmedizin (Germany)
  2. Universitätsklinik Magdeburg, Klinik für Allgemein-Viszeral- und Gefäßchirurgie (Germany)
Publication Date:
OSTI Identifier:
22756473
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 40; Journal Issue: 8; Other Information: Copyright (c) 2017 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Article Copyright (c) 2017 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOLOGICAL MARKERS; HEPATOMAS; LIVER; PATIENTS; RADIOEMBOLIZATION; RADIOPROTECTIVE SUBSTANCES

Citation Formats

Seidensticker, Max, Powerski, Maciej, Seidensticker, Ricarda, Damm, Robert, Mohnike, Konrad, Garlipp, Benjamin, Klopffleisch, Maurice, Amthauer, Holger, Ricke, Jens, and Pech, Maciej. Cytokines and {sup 90}Y-Radioembolization: Relation to Liver Function and Overall Survival. United States: N. p., 2017. Web. doi:10.1007/S00270-017-1622-4.
Seidensticker, Max, Powerski, Maciej, Seidensticker, Ricarda, Damm, Robert, Mohnike, Konrad, Garlipp, Benjamin, Klopffleisch, Maurice, Amthauer, Holger, Ricke, Jens, & Pech, Maciej. Cytokines and {sup 90}Y-Radioembolization: Relation to Liver Function and Overall Survival. United States. doi:10.1007/S00270-017-1622-4.
Seidensticker, Max, Powerski, Maciej, Seidensticker, Ricarda, Damm, Robert, Mohnike, Konrad, Garlipp, Benjamin, Klopffleisch, Maurice, Amthauer, Holger, Ricke, Jens, and Pech, Maciej. Tue . "Cytokines and {sup 90}Y-Radioembolization: Relation to Liver Function and Overall Survival". United States. doi:10.1007/S00270-017-1622-4.
@article{osti_22756473,
title = {Cytokines and {sup 90}Y-Radioembolization: Relation to Liver Function and Overall Survival},
author = {Seidensticker, Max and Powerski, Maciej and Seidensticker, Ricarda and Damm, Robert and Mohnike, Konrad and Garlipp, Benjamin and Klopffleisch, Maurice and Amthauer, Holger and Ricke, Jens and Pech, Maciej},
abstractNote = {BackgroundTo evaluate the course of pro- and anti-inflammatory cytokines after {sup 90}Y-radioembolization (RE) of liver malignancies and to identify prognosticators for liver-related adverse events and survival.MethodsIn 34 consecutive patients with secondary or primary liver tumors scheduled for RE, the following cytokines were measured prior to and 2 h, 3 days, and 6 weeks after RE: interleukin (IL) -1, IL-2, IL-4, IL-6, IL-8, tumor necrosis factor alpha (TNF-α), and interferon-γ. Liver function impairment was defined as an elevation of liver-related laboratory values as graded by CTCAE ≥ 2 and/or serum bilirubin ≥30 µmol/l and/or development of ascites at 6-week follow-up.ResultsSignificant changes over time were seen in IL-1 (increase from 0.4 pg/ml (±0.7) at baseline to 1.1 pg/ml (±1.4) 3 days after RE (p = 0.02)), and in IL-6 (increase from 16.8 pg/ml (±21.8) at baseline to 54.6 pg/ml (±78.2) 3 days after RE (p = 0.003)). Baseline values of IL-6 and IL-8 were independently associated with liver function impairment at follow-up as well as decreased survival with an optimal cutoff at 6.53 and 60.8 pg/ml, respectively.ConclusionExpected changes in pro- and anti-inflammatory cytokines after RE were shown. Furthermore, baseline values of IL-6 and IL-8 were associated with later liver dysfunction and survival. We hypothesize that these biomarkers are potential prognosticators and might help in patient selection for RE.},
doi = {10.1007/S00270-017-1622-4},
journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 8,
volume = 40,
place = {United States},
year = {2017},
month = {8}
}