Transarterial Radioembolization Following Chemoembolization for Unresectable Hepatocellular Carcinoma: Response Based on Apparent Diffusion Coefficient Change is an Independent Predictor for Survival

Journal Article · Thu Nov 15 00:00:00 EST 2018 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-018-1991-3· OSTI ID:22749740

Klompenhouwer, Elisabeth G.; Dresen, Raphaëla C. ^[1]; Verslype, Chris ^[2]; Laenen, Annouschka ^[3]; Bonne, Lawrence; Vandecaveye, Vincent; Maleux, Geert ^[1]

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1. University Hospitals Leuven, Department of Radiology (Belgium)
2. University Hospitals Leuven, Department of Digestive Oncology (Belgium)
3. KU Leuven Universiteit Hasselt, Department of Biostatistics and Statistical Bioinformatics (Belgium)

PurposeTo evaluate whether response based on contrast-enhanced magnetic resonance imaging (MRI) and apparent diffusion coefficient (ADC) change at diffusion-weighted MRI after transarterial radioembolization (TARE) can predict survival, in patients with prior transarterial chemoembolization with drug-eluting beads (DEB-TACE) for hepatocellular carcinoma (HCC).MethodsWe identified all patients who received DEB-TACE prior to TARE for HCC between 2007 and 2016. Response on MRI was determined by modified RECIST (mRECIST) and ADC change relative to pre-TARE imaging (ADCratio). Kaplan–Meier and log-rank tests were used to correlate the response/disease and treatment variables to overall survival. Multivariable Cox regression models were used to correct for confounders.ResultsA total of 29 consecutive patients were included. Univariable analysis showed that response determined by mRECIST was a nonsignificant predictor of survival (p = 0.057), and response determined by ADCratio was a significant predictor of survival (p = 0.011). Number of prior DEB-TACE procedures (p = 0.037), female gender (p < 0.001) and BCLC C (p = 0.03) were related to worse survival. The number of prior DEB-TACE procedure was significantly higher in non-responders determined by ADCratio (p = 0.028). Multivariable analyses showed that response based on ADCratio was an independent predictor of survival (p = 0.041).ConclusionADCratio following TARE is an independent predictor for survival in patients who previously underwent DEB-TACE for HCC.

• OSTI ID: 22749740
• Journal Information: Cardiovascular and Interventional Radiology, Vol. 41, Issue 11; Other Information: Copyright (c) 2018 Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); ISSN 0174-1551
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
HEPATOMAS
NMR IMAGING
PATIENTS
RADIOEMBOLIZATION