β-elemene inhibits tumor-promoting effect of M2 macrophages in lung cancer

Journal Article · Sat Aug 19 04:00:00 EDT 2017 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/J.BBRC.2017.06.071· OSTI ID:22719041

Yu, Xiaomu; Xu, Maoyi ^[1]; Li, Na ^[2]; Li, Zongjuan; Li, Hongye ^[1]; Shao, Shujuan ^[2]; Zou, Kun ^[3]; Zou, Lijuan ^[1]

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1. Department of Radiotherapy Oncology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning (China)
2. Key Laboratory of Proteomics, Dalian Medical University, Dalian, Liaoning (China)
3. Department of Radiotherapy Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning (China)

Macrophages in tumor are mostly M2-polarized and have been reported to promote tumorigenesis, which are also defined as tumor-associated macrophages (TAMs). β-elemene has therapeutic effects against several cancers, however, it remains unknown whether β-elemene could inhibit cancer by targeting TAMs. Herein, we examined the effect of β-elemene on macrophages to elucidate a novel mechanism of β-elemene in tumor therapy. We showed that the conditioned medium of M2 macrophages promoted lung cancer cells to migration, invasion and epithelial mesenchymal transition, which could be inhibited by β-elemene. Moreover, β-elemene regulated the polarization of macrophages from M2 to M1. β-elemene also inhibited the proliferation, migration, invasion of lung cancer cells and enhanced its radiosensitivity. These results indicate β-elemene suppresses lung cancer by regulating both macrophages and lung cancer cells, it is a promising drug for combination with chemotherapy or radiotherapy. - Highlights: • β-elemene inhibits M2 macrophages induced migration and invasion of cancer cells. • β-elemene inhibits M2 macrophages induced EMT in lung cancer cells. • β-elemene transforms macrophages from M2 to M1 phenotype. • This study reveals a novel anti-tumor mechanism of β-elemene.

• OSTI ID: 22719041
• Journal Information: Biochemical and Biophysical Research Communications, Journal Name: Biochemical and Biophysical Research Communications Journal Issue: 2 Vol. 490; ISSN 0006-291X; ISSN BBRCA9
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
CHEMOTHERAPY
DRUGS
LUNGS
MACROPHAGES
NEOPLASMS
PHENOTYPE
POLARIZATION
RADIOSENSITIVITY
RADIOTHERAPY
TAMOXIFEN