LY6/PLAUR domain containing 3 has a role in the maintenance of colorectal cancer stem-like cells

Journal Article · Sat Apr 29 00:00:00 EDT 2017 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/J.BBRC.2017.02.112· OSTI ID:22696981

Wang, Liming ^[1]; Hirohashi, Yoshihiko ^[1]; Ogawa, Tadashi ^[1]; Shen, Min; Takeda, Rui; Murai, Aiko; Yamamoto, Eri; Kubo, Terufumi; Nakatsugawa, Munehide; Kanaseki, Takayuki; Tsukahara, Tomohide ^[1]; Nishidate, Toshihiko; Okita, Kenji; Kutomi, Goro ^[2]; Sato, Noriyuki ^[1]; Takemasa, Ichiro ^[2]; Torigoe, Toshihiko ^[1]

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1. Department of Pathology, Sapporo Medical University School of Medicine, South-1 West-17, Chuo-Ku, Sapporo 060-8556 (Japan)
2. Department of Surgery, Sapporo Medical University School of Medicine, South-1 West-17, Chuo-Ku, Sapporo 060-8556 (Japan)

Colorectal carcinoma (CRC) is one of the most frequently diagnosed cancers and the leading cause of cancer-related death for both men and women. Recent studies have revealed that a small sub-population of cancer cells, termed cancer stem-like cells (CSCs)/cancer-initiating cells (CICs), are endowed with tumor-initiating ability, self-renewal ability and differentiation ability. CSCs/CICs are resistant to current therapies including chemotherapy and radiotherapy. Thus, CSCs/CICs are responsible for recurrence and metastasis, and eradication of CSCs/CICs is essential to cure cancer. In this study, we isolated CR-CSCs/CICs as sphere-cultured cells and found that a product derived from LY6/PLAUR domain containing 3 (LYPD3) is preferentially expressed in CSCs/CICs. Gene overexpression and gene knockdown experiments revealed that LYPD3 has a role in the maintenance of CR-CSCs/CICs. The findings provide a novel molecular insight into CR-CSCs/CICs.

• OSTI ID: 22696981
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 486, Issue 2; Other Information: Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
CARCINOMAS
CELL CULTURES
CHEMOTHERAPY
CURRENTS
DEATH
DIAGNOSIS
GENES
MAINTENANCE
MEN
METASTASES
POPULATIONS
RADIOTHERAPY
SPHERES
STEM CELLS
WOMEN