Highly expressed lncRNA CCND2-AS1 promotes glioma cell proliferation through Wnt/β-catenin signaling
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing (China)
- Department of Endocrinology, Taian City Central Hospital, Taian (China)
- Department of Oncology, Taian City Central Hospital, Taian (China)
Glioma is the most common and aggressive primary brain tumor in adults. Long-non coding RNAs (lncRNAs) have been recently shown to play important roles in regulating numerous biological processes both in physiologic and pathologic condition. However, the role of lncRNAs in glioma remains largely unknown. In this study, we firstly found that lncRNA CCND2-AS2 is significantly up regulated in malignant glioma tissues and cell lines. Both loss- and gain-functions assays show that CCND2-AS1 promotes glioma cells proliferation and growth. In addition, we also revealed that highly expressed CCND2-AS1 could enhance Wnt/β-catenin signaling in glioma. Taken together, our findings revealed a novel lncRNA CCND2-AS1 promotes glioma cell proliferation through Wnt/β-catenin signaling and CCND2-AS1 might function as a potential novel therapeutic target for the treatment of glioma. - Highlights: • LncRNA CCND2-AS1 was significantly upregulated in glioma cancer tissues and cell lines. • Overexpression CCND2-AS1 confers a poor prognosis in glioma patients. • Knockdown of CCND2-AS1 inhibited glioma cell proliferation and induced cell cycle arrest. • Overexpression CCND2-AS1 promotes cell growth in Normal human astrocyte (NHA). • LncRNA CCND2-AS1 regulates the activation of Wnt/β-catenin signaling in glioma cells.
- OSTI ID:
- 22696800
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 482, Issue 4; Other Information: Copyright (c) 2016 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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