SPOCK1 is up-regulated and promotes tumor growth via the PI3K/AKT signaling pathway in colorectal cancer

Journal Article · Sun Jan 22 00:00:00 EST 2017 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/J.BBRC.2016.11.126· OSTI ID:22696782

Zhang, Jiaxuan; Zhi, Xiaofei ^[1]; Shi, Shiyu ^[2]; Tao, Ran; Chen, Peisheng; Sun, Shiyu; Bian, Longjun ^[1]; Xu, Zhangyan ^[2]; Ma, Lilin ^[1]

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1. Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu (China)
2. Medical College, Nantong University, Nantong, 226001, Jiangsu (China)

SPOCK1 encodes a Ca{sup 2+}-binding matricellular glycoprotein which plays an oncogenic role in cancer cells. However, the role of SPOCK1 in the pathogenesis of colorectal cancer (CRC) has not been determined. Here, SPOCK1 was found higher expressed in CRC tissues than that of adjacent normal tissues. Furthermore, up-regulated expression of SPOCK1 in CRC patients was associated with tumor size and TNM stage. In addition, we observed that the depletion of SPOCK1 inhibited proliferation in vitro and tumorigenicity in vivo and promoted apoptosis in cell culture. Our data suggest that inactivation of PI3K/Akt signaling pathway was involved in down-regulation of SPOCK1-mediated suppression of tumor cell proliferation. These results suggest that SPOCK1 expression is correlated with malignant features of CRC and may serve as potential therapeutic and preventive strategies for CRC. - Highlights: • SPOCK1 expression is significantly up-regulated in CRC tissues and associated with tumor size and TMN stage. • Down-regulation of SPOCK1 suppresses CRC cell proliferation both in vitro and in vivo. • SPOCK1 stimulates the PI3K/AKT signaling pathway to inhibit cell apoptosis and promote tumor growth.

• OSTI ID: 22696782
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 482, Issue 4; Other Information: Copyright (c) 2016 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ANIMAL TISSUES
CELL CULTURES
CELL PROLIFERATION
IN VITRO
IN VIVO
INHIBITION
NEOPLASMS
PLANT GROWTH
PLANT TISSUES
SIGNALS
TUMOR CELLS