Placental biomarkers of PAH exposure and glutathione-S-transferase biotransformation enzymes in an obstetric population from Tijuana, Baja California, Mexico

Journal Article · Sun Jan 15 04:00:00 EST 2017 · Environmental Research

DOI:https://doi.org/10.1016/J.ENVRES.2016.04.019· OSTI ID:22689530

Dodd-Butera, Teresa ^[1]; Ramirez-Zetina, Martha ^[2]; Shaputnic, Carolyn ^[3]; Garcia-Castillo, Maura ^[4]; Ingmanson, Sonja ^[3]; Hull, Stacy ^[3]

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1. California State University San Bernardino, Department of Nursing, 5500 University Parkway, San Bernardino, CA 92407 (United States)
2. Instituto Mexicano del Seguro Social Tijuana, BC (Mexico)
3. San Diego State University, Graduate School of Public Health, San Diego, CA (United States)
4. Xochicalco Universidad Escuela de Medicina, BC (Mexico)

Environmental exposures along the US-Mexico border have the potential to adversely affect the maternal-fetal environment. The purpose of this study was to assess placental biomarkers of environmental exposures in an obstetric population at the California-Baja California border in relation to detoxifying enzymes in the placenta and nutritional status. This study was conducted on consenting, full-term, obstetric patients (n=54), delivering in a hospital in Tijuana, Baja California (BC), Mexico. Placental polyaromatic hydrocarbon (PAH)-DNA adducts were measured in addition to placental glutathione-S-transferase (GST) activity and genotype, maternal serum folate, and maternal and umbilical cord blood lead and cadmium levels. A questionnaire was administered to the mothers to determine maternal occupation in a maquiladora, other exposures, and obstetric indicators. In univariate analysis, maternal serum folate levels were inversely correlated with total PAH-DNA adducts (rho=−0.375, p=0.007); adduct #1 (rho=−0.388, p=0.005); and adduct #3 (rho =−0.430, p=0.002). Maternal lead levels were significantly positively correlated with cord blood lead levels (rho=0.512, p<0.001). Cadmium levels were generally very low but significantly higher in mothers exposed to environmental tobacco smoke (ETS) (either at work or at home, n=10). In multivariate analysis, only maternal serum folate levels remained as a significant negative predictor of total DNA-PAH adducts levels in placenta. These findings affirm that placental tissue is a valuable and readily available source of human tissue for biomonitoring; and indicate that further study of the role of nutrition in detoxification and mitigation of environmental exposures in pregnant women is warranted. - Highlights: • Maternal-fetal environment susceptible to toxic exposures at US-Mexico border. • Lower serum folate was correlated with higher PAH-DNA adduct levels at birth. • Placental DNA adducts in GST mu (-) cord blood were higher than GST(+) genotype. • Blood lead levels in Mexican women were higher than reported to NHANES. • Cadmium levels in mothers exposed to ETS correlated with total PAH-DNA adducts.

• OSTI ID: 22689530
• Journal Information: Environmental Research, Journal Name: Environmental Research Vol. 152; ISSN ENVRAL; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ANIMAL TISSUES
BIOLOGICAL MARKERS
BLOOD
DNA
DNA ADDUCTS
GENOTYPE
GLUTATHIONE
POLYCYCLIC AROMATIC HYDROCARBONS
TOBACCO SMOKES
WOMEN