Circulating levels of perfluoroalkyl substances are associated with dietary patterns – A cross sectional study in elderly Swedish men and women

Journal Article · Sat Oct 15 04:00:00 EDT 2016 · Environmental Research

DOI:https://doi.org/10.1016/J.ENVRES.2016.05.016· OSTI ID:22689483

Sjogren, Per ^[1]; Montse, Rachel ^[1]; Lampa, Erik ^[2]; Salihovic, Samira ^[3]; Lind, Lars ^[4]

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1. Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala (Sweden)
2. Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala (Sweden)
3. Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala (Sweden)
4. Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala (Sweden)

Background: In our daily life, we are exposed to perfluoroalkyl substances (PFAS) with possible health implications. The main exposure route for these substances is diet but comparative studies on how dietary habits influence exposure are lacking. Objectives: To examine the relations between blood levels of PFAS and adherence to three predefined dietary patterns (a WHO recommended diet, a Mediterranean-like diet, and a Low-Carbohydrate High-Protein (LCHP) diet) in an elderly Swedish population. Methods: Dietary data from 7-day food records and serum concentrations of PFAS were obtained from a 70-year-old Swedish population (n=844), the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. The Healthy Diet Indicator score (based on WHO recommendations), the Mediterranean Diet Score and LCHP score were used to assess adherence. Multivariate linear regression was used to assess the associations between eight major PFAS and adherence to each dietary pattern. Results: The WHO recommended diet was positively associated with perfluorohexane sulfonic acid (PFHxS). The LCHP diet was positively related to four out of eight PFAS; namely, perfluorooctane sulfonic acid (PFOS), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA) and perfluoroundecanoic acid (PFUnDA). The Mediterranean-like diet was positively associated with most PFAS; namely perfluorooctanoic acid (PFOA), perfluorooctane sulfonamide (PFOSA), PFHxS, PFNA, PFDA, and PFUnDA. Conclusions: All dietary patterns were positively associated with blood levels of PFAS. The highest body burden of PFAS was found in individuals with high adherence to a Mediterranean-like diet, whilst individuals who more closely followed the officially recommended diet displayed a lower body burden of these compounds. - Highlights: • Perfluoroalkyl substances (PFAS) quantified in blood of 70-y-old Swedish subjects. • Adherence to predefined dietary patterns was associated with circulating PFAS. • A Mediterranean-like diet was positively associated with most circulating PFAS. • A low-carbohydrate high-protein diet was positively related to some PFAS in blood. • A WHO-recommended diet was only related to higher circulating levels of PFHxS.

• OSTI ID: 22689483
• Journal Information: Environmental Research, Journal Name: Environmental Research Vol. 150; ISSN ENVRAL; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
60 APPLIED LIFE SCIENCES
BLOOD
BODY BURDEN
CARBOHYDRATES
DIET
ECOLOGICAL CONCENTRATION
MULTIVARIATE ANALYSIS
SULFONAMIDES
SULFONIC ACIDS