Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry
- Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States)
- Department of Computer Science, University College London, London WC1E 7JE (United Kingdom)
- Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States)
- Division of Neurology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 (United States)
- Faculty of Electrical Engineering, University of Ljubljana, Ljubljana 1000 (Slovenia)
- Daegu Gyeongbuk Institute of Science and Technology, Daegu 711-813 (Korea, Republic of)
- Department of Biomedical Engineering, University of Rochester, Rochester, New York 14642 (United States)
- Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States)
Purpose: The authors introduce a state-of-the-art all-optical clinical diffuse optical tomography (DOT) imaging instrument which collects spatially dense, multispectral, frequency-domain breast data in the parallel-plate geometry. Methods: The instrument utilizes a CCD-based heterodyne detection scheme that permits massively parallel detection of diffuse photon density wave amplitude and phase for a large number of source–detector pairs (10{sup 6}). The stand-alone clinical DOT instrument thus offers high spatial resolution with reduced crosstalk between absorption and scattering. Other novel features include a fringe profilometry system for breast boundary segmentation, real-time data normalization, and a patient bed design which permits both axial and sagittal breast measurements. Results: The authors validated the instrument using tissue simulating phantoms with two different chromophore-containing targets and one scattering target. The authors also demonstrated the instrument in a case study breast cancer patient; the reconstructed 3D image of endogenous chromophores and scattering gave tumor localization in agreement with MRI. Conclusions: Imaging with a novel parallel-plate DOT breast imager that employs highly parallel, high-resolution CCD detection in the frequency-domain was demonstrated.
- OSTI ID:
- 22689480
- Journal Information:
- Medical Physics, Vol. 43, Issue 7; Other Information: (c) 2016 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-2405
- Country of Publication:
- United States
- Language:
- English
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