Air pollution exposure and preeclampsia among US women with and without asthma

Journal Article · Fri Jul 15 04:00:00 EDT 2016 · Environmental Research

DOI:https://doi.org/10.1016/J.ENVRES.2016.04.004· OSTI ID:22687747

Mendola, Pauline ^[1]; Wallace, Maeve ^[1]; Liu, Danping ^[2]; Robledo, Candace ^[1]; Männistö, Tuija ^[1]; Grantz, Katherine L. ^[1]

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1. Eunice Kennedy Shriver National Institute of Child Health and Human Development, Division of Intramural Population Health Research, Epidemiology Branch, Rockville, MD 20852 (United States)
2. Eunice Kennedy Shriver National Institute of Child Health and Human Development, Division of Intramural Population Health Research, Biostatistics and Bioinformatics Branch, Rockville, MD 20852 (United States)

Maternal asthma and air pollutants have been independently associated with preeclampsia but rarely studied together. Our objective was to comprehensively evaluate preeclampsia risk based on the interaction of maternal asthma and air pollutants. Preeclampsia and asthma diagnoses, demographic and clinical data came from electronic medical records for 210,508 singleton deliveries. Modified Community Multiscale Air Quality models estimated preconception, first and second trimester and whole pregnancy exposure to: particulate matter (PM)<2.5 and <10 µm, ozone, nitrogen oxides (NO{sub x}), sulfur dioxide (SO{sub 2}) and carbon monoxide (CO); PM{sub 2.5} constituents; volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs). Asthma-pollutant interaction adjusted relative risks (RR) and 95% confidence intervals (CI) for preeclampsia were calculated by interquartile range for criteria pollutants and high exposure (≥75th percentile) for PAHs and VOCs. Asthmatics had higher risk associated with first trimester NO{sub x} and SO{sub 2} and whole pregnancy elemental carbon (EC) exposure than non-asthmatics, but only EC significantly increased risk (RR=1.11, CI:1.03–1.21). Asthmatics also had a 10% increased risk associated with second trimester CO. Significant interactions were observed for nearly all VOCs and asthmatics had higher risk during all time windows for benzene, ethylbenzene, m-xylene, o-xylene, p-xylene and toluene while most PAHs did not increase risk. - Highlights: • Asthma is common in pregnancy and asthmatic women have increased preeclampsia risk. • Air pollution could differentially increase preeclampsia risk for asthmatic women. • Preeclampsia risk was higher for asthmatics than non-asthmatics after VOC exposure. • Asthmatics also had higher risk after whole pregnancy exposure to elemental carbon. • Pregnant women with asthma appear to be particularly vulnerable to air pollutants.

• OSTI ID: 22687747
• Journal Information: Environmental Research, Journal Name: Environmental Research Vol. 148; ISSN ENVRAL; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
AIR
AIR POLLUTION
AIR QUALITY
ASTHMA
BENZENE
CARBON MONOXIDE
MEDICAL RECORDS
NITROGEN DIOXIDE
OZONE
POLLUTANTS
POLYCYCLIC AROMATIC HYDROCARBONS
PREGNANCY
SULFUR DIOXIDE
TOLUENE
VOLATILE MATTER
XYLENES