Self‐Propelling Macroscale Sheets Powered by Enzyme Pumps

Song, Jiaqi; Shklyaev, Oleg E.; Sapre, Aditya; Balazs, Anna C.; Sen, Ayusman

doi:10.1002/ange.202311556

Self‐Propelling Macroscale Sheets Powered by Enzyme Pumps

Journal Article · Thu Dec 28 23:00:00 EST 2023 · Angewandte Chemie

DOI:https://doi.org/10.1002/ange.202311556· OSTI ID:2267606

Song, Jiaqi ^[1]; ^[2]; Sapre, Aditya ^[3]; ^[2]; ^[4]

Department of Chemistry The Pennsylvania State University University Park PA-16802 USA
Department of Chemical Engineering University of Pittsburgh Pittsburgh PA-15260 USA
Department of Chemical Engineering The Pennsylvania State University University Park PA-16802 USA
Department of Chemistry The Pennsylvania State University University Park PA-16802 USA, Department of Chemical Engineering The Pennsylvania State University University Park PA-16802 USA

Abstract

Nanoscale enzymes anchored to surfaces act as chemical pumps by converting chemical energy released from enzymatic reactions into spontaneous fluid flow that propels entrained nano‐ and microparticles. Enzymatic pumps are biocompatible, highly selective, and display unique substrate specificity. Utilizing these pumps to trigger self‐propelled motion on the macroscale has, however, constituted a significant challenge and thus prevented their adaptation in macroscopic fluidic devices and soft robotics. Using experiments and simulations, we herein show that enzymatic pumps can drive centimeter‐scale polymer sheets along directed linear paths and rotational trajectories. In these studies, the sheets are confined to the air/water interface. With the addition of appropriate substrate, the asymmetric enzymatic coating on the sheets induces chemically driven, buoyancy flows that controllably propel the sheet's motion on the air/water interface. The directionality and speed of the motion can be tailored by changing the pattern of the enzymatic coating, type of enzyme, and nature and concentration of the substrate. This work highlights the utility of biocompatible enzymes for generating motion in macroscale fluidic devices and robotics and indicates their potential utility for in vivo applications.

View Journal Article

Sponsoring Organization:: USDOE

Grant/Contract Number:: NONE; FG02-90ER45438; SC0020964

OSTI ID:: 2267606

Journal Information:: Angewandte Chemie, Journal Name: Angewandte Chemie Journal Issue: 6 Vol. 136; ISSN 0044-8249

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: Germany

Language:: English

References (19)

Enzyme Micropump-Based Inhibitor Assays Ortiz-Rivera, Isamar; Courtney, Taylor M.; Sen, Ayusman Advanced Functional Materials, Vol. 26, Issue 13 https://doi.org/10.1002/adfm.201504619	journal	February 2016
Powering Motion with Enzymes Zhao, Xi; Gentile, Kayla; Mohajerani, Farzad Accounts of Chemical Research, Vol. 51, Issue 10 https://doi.org/10.1021/acs.accounts.8b00286	journal	September 2018
Convective Self-Sustained Motion in Mixtures of Chemically Active and Passive Particles Shklyaev, Oleg E.; Shum, Henry; Yashin, Victor V. Langmuir, Vol. 33, Issue 32 https://doi.org/10.1021/acs.langmuir.7b01840	journal	August 2017
Achieving Independent Control over Surface and Bulk Fluid Flows in Microchambers Tansi, Benjamin M.; Manna, Raj Kumar; Shklyaev, Oleg E. ACS Applied Materials & Interfaces, Vol. 13, Issue 5 https://doi.org/10.1021/acsami.0c21291	journal	February 2021
Geometric and Scaling Effects in the Speed of Catalytic Enzyme Micropumps Gao, Tianyue; McNeill, Jeffrey M.; Oliver, Vincent A. ACS Applied Materials & Interfaces, Vol. 14, Issue 34 https://doi.org/10.1021/acsami.2c09555	journal	August 2022
Light-Powered, Fuel-Free Oscillation, Migration, and Reversible Manipulation of Multiple Cargo Types by Micromotor Swarms Zhang, Jianhua; Laskar, Abhrajit; Song, Jiaqi ACS Nano, Vol. 17, Issue 1 https://doi.org/10.1021/acsnano.2c07266	journal	November 2022
Self-Assembled Phage-Based Colloids for High Localized Enzymatic Activity Alarcón-Correa, Mariana; Günther, Jan-Philipp; Troll, Jonas ACS Nano, Vol. 13, Issue 5 https://doi.org/10.1021/acsnano.9b01408	journal	March 2019
Self-powered enzyme micropumps Sengupta, Samudra; Patra, Debabrata; Ortiz-Rivera, Isamar Nature Chemistry, Vol. 6, Issue 5 https://doi.org/10.1038/nchem.1895	journal	March 2014
Computer modeling reveals modalities to actuate mutable, active matter Laskar, Abhrajit; Manna, Raj Kumar; Shklyaev, Oleg E. Nature Communications, Vol. 13, Issue 1 https://doi.org/10.1038/s41467-022-30445-x	journal	May 2022
Bioinspired microrobots Palagi, Stefano; Fischer, Peer Nature Reviews Materials, Vol. 3, Issue 6 https://doi.org/10.1038/s41578-018-0016-9	journal	May 2018
Breaking the chains: deubiquitylating enzyme specificity begets function Clague, Michael J.; Urbé, Sylvie; Komander, David Nature Reviews Molecular Cell Biology, Vol. 20, Issue 6 https://doi.org/10.1038/s41580-019-0099-1	journal	February 2019
Chemistry pumps: a review of chemically powered micropumps Zhou, Chao; Zhang, Hua; Li, Zeheng Lab on a Chip, Vol. 16, Issue 10 https://doi.org/10.1039/C6LC00032K	journal	January 2016
Solutal and thermal buoyancy effects in self-powered phosphatase micropumps Valdez, Lyanne; Shum, Henry; Ortiz-Rivera, Isamar Soft Matter, Vol. 13, Issue 15 https://doi.org/10.1039/C7SM00022G	journal	January 2017
Convective flow reversal in self-powered enzyme micropumps Ortiz-Rivera, Isamar; Shum, Henry; Agrawal, Arjun Proceedings of the National Academy of Sciences, Vol. 113, Issue 10 https://doi.org/10.1073/pnas.1517908113	journal	February 2016
Designing self-propelled, chemically active sheets: Wrappers, flappers, and creepers Laskar, Abhrajit; Shklyaev, Oleg E.; Balazs, Anna C. Science Advances, Vol. 4, Issue 12 https://doi.org/10.1126/sciadv.aav1745	journal	December 2018
Motor Proteins at Work for Nanotechnology van den Heuvel, M. G. L.; Dekker, C. Science, Vol. 317, Issue 5836 https://doi.org/10.1126/science.1139570	journal	July 2007
Enzyme-powered Janus platelet cell robots for active and targeted drug delivery Tang, Songsong; Zhang, Fangyu; Gong, Hua Science Robotics, Vol. 5, Issue 43 https://doi.org/10.1126/scirobotics.aba6137	journal	June 2020
Swarming behavior and in vivo monitoring of enzymatic nanomotors within the bladder Hortelao, Ana C.; Simó, Cristina; Guix, Maria Science Robotics, Vol. 6, Issue 52 https://doi.org/10.1126/scirobotics.abd2823	journal	March 2021
A method for determination of the capacity of urea synthesis in the rat Hansen, Bent Adel; Vilstrup, Hendrik Scandinavian Journal of Clinical and Laboratory Investigation, Vol. 45, Issue 4 https://doi.org/10.3109/00365518509161013	journal	January 1985

Similar Records

Self‐Propelling Macroscale Sheets Powered by Enzyme Pumps

Journal Article · Thu Dec 28 23:00:00 EST 2023 · Angewandte Chemie (International Edition) · OSTI ID:2267592

Self‐Propelling Macroscale Sheets Powered by Enzyme Pumps

Citation Formats

References (19)

Similar Records

Related Subjects