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Title: The 2-Year Cosmetic Outcome of a Randomized Trial Comparing Prone and Supine Whole-Breast Irradiation in Large-Breasted Women

Abstract

Purpose: To report the 2-year cosmetic outcome of a randomized trial comparing prone and supine whole-breast irradiation in large-breasted patients. Methods and Materials: One hundred patients with a (European) cup size ≥C were included. Before and 2 years after radiation therapy, clinical endpoints were scored and digital photographs were taken with the arms alongside the body and with the arms elevated 180°. Three observers rated the photographs using the 4-point Harvard cosmesis scale. Cosmesis was also evaluated with the commercially available Breast Cancer Conservation Treatment.cosmetic results (BCCT.core) software. Results: Two-year follow-up data and photographs were available for 94 patients (47 supine treated and 47 prone treated). Patient and treatment characteristics were not significantly different between the 2 cohorts. A worsening of color change occurred more frequently in the supine than in the prone cohort (19/46 vs 10/46 patients, respectively, P=.04). Five patients in the prone group (11%) and 12 patients in the supine group (26%) presented with a worse scoring of edema at 2-year follow-up (P=.06). For retraction and fibrosis, no significant differences were found between the 2 cohorts, although scores were generally worse in the supine cohort. The cosmetic scoring by 3 observers did not reveal differences between the prone andmore » supine groups. On the photographs with the hands up, 7 patients in the supine group versus none in the prone group had a worsening of cosmesis of 2 categories using the (BCCT.org) software (P=.02). Conclusion: With a limited follow-up of 2 years, better cosmetic outcome was observed in prone-treated than in supine-treated patients.« less

Authors:
 [1];  [2]; ; ; ;  [1];  [1];  [2];  [1];  [1];  [2]
  1. Department of Radiation Oncology, University Hospital Ghent, Ghent (Belgium)
  2. (Belgium)
Publication Date:
OSTI Identifier:
22648737
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 95; Journal Issue: 4; Other Information: Copyright (c) 2016 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; COMPUTER CODES; CONSUMER PRODUCTS; IMAGES; IRRADIATION; MAMMARY GLANDS; PATIENTS; PHOTOGRAPHY; RADIOTHERAPY

Citation Formats

Veldeman, Liv, E-mail: liv.veldeman@uzgent.be, Department of Radiotherapy and Experimental Cancer Research, Ghent University, Ghent, Schiettecatte, Kimberly, De Sutter, Charlotte, Monten, Christel, Greveling, Annick van, Berkovic, Patrick, Department of Radiation Oncology, Centre Hospitalier Universitaire de Liège, Liège, Mulliez, Thomas, De Neve, Wilfried, and Department of Radiotherapy and Experimental Cancer Research, Ghent University, Ghent. The 2-Year Cosmetic Outcome of a Randomized Trial Comparing Prone and Supine Whole-Breast Irradiation in Large-Breasted Women. United States: N. p., 2016. Web. doi:10.1016/J.IJROBP.2016.03.003.
Veldeman, Liv, E-mail: liv.veldeman@uzgent.be, Department of Radiotherapy and Experimental Cancer Research, Ghent University, Ghent, Schiettecatte, Kimberly, De Sutter, Charlotte, Monten, Christel, Greveling, Annick van, Berkovic, Patrick, Department of Radiation Oncology, Centre Hospitalier Universitaire de Liège, Liège, Mulliez, Thomas, De Neve, Wilfried, & Department of Radiotherapy and Experimental Cancer Research, Ghent University, Ghent. The 2-Year Cosmetic Outcome of a Randomized Trial Comparing Prone and Supine Whole-Breast Irradiation in Large-Breasted Women. United States. doi:10.1016/J.IJROBP.2016.03.003.
Veldeman, Liv, E-mail: liv.veldeman@uzgent.be, Department of Radiotherapy and Experimental Cancer Research, Ghent University, Ghent, Schiettecatte, Kimberly, De Sutter, Charlotte, Monten, Christel, Greveling, Annick van, Berkovic, Patrick, Department of Radiation Oncology, Centre Hospitalier Universitaire de Liège, Liège, Mulliez, Thomas, De Neve, Wilfried, and Department of Radiotherapy and Experimental Cancer Research, Ghent University, Ghent. Fri . "The 2-Year Cosmetic Outcome of a Randomized Trial Comparing Prone and Supine Whole-Breast Irradiation in Large-Breasted Women". United States. doi:10.1016/J.IJROBP.2016.03.003.
@article{osti_22648737,
title = {The 2-Year Cosmetic Outcome of a Randomized Trial Comparing Prone and Supine Whole-Breast Irradiation in Large-Breasted Women},
author = {Veldeman, Liv, E-mail: liv.veldeman@uzgent.be and Department of Radiotherapy and Experimental Cancer Research, Ghent University, Ghent and Schiettecatte, Kimberly and De Sutter, Charlotte and Monten, Christel and Greveling, Annick van and Berkovic, Patrick and Department of Radiation Oncology, Centre Hospitalier Universitaire de Liège, Liège and Mulliez, Thomas and De Neve, Wilfried and Department of Radiotherapy and Experimental Cancer Research, Ghent University, Ghent},
abstractNote = {Purpose: To report the 2-year cosmetic outcome of a randomized trial comparing prone and supine whole-breast irradiation in large-breasted patients. Methods and Materials: One hundred patients with a (European) cup size ≥C were included. Before and 2 years after radiation therapy, clinical endpoints were scored and digital photographs were taken with the arms alongside the body and with the arms elevated 180°. Three observers rated the photographs using the 4-point Harvard cosmesis scale. Cosmesis was also evaluated with the commercially available Breast Cancer Conservation Treatment.cosmetic results (BCCT.core) software. Results: Two-year follow-up data and photographs were available for 94 patients (47 supine treated and 47 prone treated). Patient and treatment characteristics were not significantly different between the 2 cohorts. A worsening of color change occurred more frequently in the supine than in the prone cohort (19/46 vs 10/46 patients, respectively, P=.04). Five patients in the prone group (11%) and 12 patients in the supine group (26%) presented with a worse scoring of edema at 2-year follow-up (P=.06). For retraction and fibrosis, no significant differences were found between the 2 cohorts, although scores were generally worse in the supine cohort. The cosmetic scoring by 3 observers did not reveal differences between the prone and supine groups. On the photographs with the hands up, 7 patients in the supine group versus none in the prone group had a worsening of cosmesis of 2 categories using the (BCCT.org) software (P=.02). Conclusion: With a limited follow-up of 2 years, better cosmetic outcome was observed in prone-treated than in supine-treated patients.},
doi = {10.1016/J.IJROBP.2016.03.003},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 4,
volume = 95,
place = {United States},
year = {Fri Jul 15 00:00:00 EDT 2016},
month = {Fri Jul 15 00:00:00 EDT 2016}
}