Pharmacokinetics and Histopathological Findings of Chemoembolization Using Cisplatin Powder Mixed with Degradable Starch Microspheres in a Rabbit Liver Tumor Model

Journal Article · Wed Mar 15 00:00:00 EDT 2017 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-016-1512-1· OSTI ID:22645309

Sato, Takeshi; Tanaka, Toshihiro; Nishiofuku, Hideyuki; Fukuoka, Yasushi ^[1]; Sakaguchi, Hiroshi ^[2]; Masada, Tetsuya; Tatsumoto, Shota ^[1]; Marugami, Nagaaki ^[3]; Takano, Masato ^[4]; Yamato, Ichiro; Sho, Masayuki ^[5]; Ohbayashi, Chiho ^[4]; Hirai, Toshiko ^[3]; Kichikawa, Kimihiko ^[1]

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1. IVR CenterNara Medical University, Department of Radiology (Japan)
2. South Nara General Medical Center, Department of Radiology (Japan)
3. Diagnostic Imaging Center, Department of Radiology (Japan)
4. Nara Medical University, Department of Diagnostic Pathology (Japan)
5. Nara Medical University, Department of Surgery (Japan)

PurposeThe purpose of this study is to evaluate the pharmacokinetics and histopathological findings of transarterial chemoembolization (TACE) using cisplatin powder mixed with degradable starch microspheres (DSM) (Cis/DSM-TACE) compared with cisplatin arterial infusion (Cis-AI).Materials and MethodsEighteen rabbits with VX2 liver tumors were divided into two groups: Cis/DSM-TACE (n = 9) and Cis-AI (n = 9) groups. In the Cis/DSM-TACE group, a mixture of cisplatin powder and DSM was injected until stasis of hepatic arterial flow was achieved. In the Cis-AI group, cisplatin solution was infused.ResultsThe platinum concentrations in VX2 tumors in the Cis/DSM-TACE group at 24 and 72 h were significantly elevated compared with those in the Cis-AI group (P = .016 and .019, respectively). There were no significant differences in the platinum concentrations in plasma. Histopathological examination revealed the presence of several microspheres inside the tumors at 1 h, which completely disappeared at 24 h. Tumor cell apoptosis at 1 h in the Cis/DSM-TACE group was more frequently observed compared with that in the Cis-AI group (P = .006).ConclusionsTACE using cisplatin powder mixed with DSM provides a higher drug concentration in tumors, thereby achieving stronger antitumor effects compared with arterial infusion of cisplatin solution.

• OSTI ID: 22645309
• Journal Information: Cardiovascular and Interventional Radiology, Journal Name: Cardiovascular and Interventional Radiology Journal Issue: 3 Vol. 40; ISSN 0174-1551; ISSN CAIRDG
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
APOPTOSIS
DRUGS
INFUSION
LIVER
MICROSPHERES
NEOPLASMS
PLATINUM
STARCH
TUMOR CELLS