Emergence of cytotoxic resistance in cancer cell populations: Single-cell mechanisms and population-level consequences

Journal Article · Wed Jun 08 00:00:00 EDT 2016 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.4952112· OSTI ID:22608982

Lorenzi, Tommaso ^[1]; Chisholm, Rebecca H. ^[2]; Lorz, Alexander; Neves de Almeida, Luís; Clairambault, Jean ^[3]; Larsen, Annette K.; Escargueil, Alexandre ^[4]

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1. Centre de Mathématiques et de Leurs Applications, ENS Cachan, CNRS, Cachan 94230 Cedex, France & INRIA-Paris-Rocquencourt, MAMBA Team, Domaine de Voluceau, BP105, 78153 Le Chesnay Cedex (France)
2. School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney NSW 2052 (Australia)
3. Sorbonne Universités, UPMC Univ Paris 06, UMR 7598, Laboratoire Jacques-Louis Lions, F-75005, Paris (France)
4. Sorbonne Universités, UPMC Univ Paris 06, F-75005, Paris (France)

We formulate an individual-based model and a population model of phenotypic evolution, under cytotoxic drugs, in a cancer cell population structured by the expression levels of survival-potential and proliferation-potential. We apply these models to a recently studied experimental system. Our results suggest that mechanisms based on fundamental laws of biology can reversibly push an actively-proliferating, and drug-sensitive, cell population to transition into a weakly-proliferative and drug-tolerant state, which will eventually facilitate the emergence of more potent, proliferating and drug-tolerant cells.

• OSTI ID: 22608982
• Journal Information: AIP Conference Proceedings, Journal Name: AIP Conference Proceedings Journal Issue: 1 Vol. 1738; ISSN 0094-243X; ISSN APCPCS
• Country of Publication: United States
• Language: English

Related Subjects

71 CLASSICAL AND QUANTUM MECHANICS
GENERAL PHYSICS
BIOLOGY
BIOPHYSICS
DRUGS
EVOLUTION
LAWS
NEOPLASMS
POPULATIONS
POTENTIALS
PROLIFERATION
SIMULATION