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Title: Scaling animal to human biodistribution of the radiopharmaceutical [68Ga]Ga-PSMA-HBED-CC

Abstract

The radiotracer called {sup 68}Ga-labelled Glu-urea-Lys(Ahx)-HBED-CC ([68Ga]Ga-PSMA-HBED-CC) is a novel radiophar-maceutical for the detection of prostate cancer lesions by positron emission tomography (PET) imaging. Setting up a cost-effective manual synthesis of this radiotracer and making its clinical translation in Colombia will require two important elements: the evaluation of the procedure to yield a consistent product, meeting standards of radio-chemical purity and low toxicity and then, the evaluation of the radiation dosimetry. In this paper a protocol to extrapolate the biokinetic model made in normal mice to humans by using the computer software for internal dose assessment OLINDA/EXM® is presented as an accurate and standardized method for the calculation of radiation dosimetry estimates.

Authors:
;  [1]
  1. Grupo de Física Nuclear, Departamento de Física, Universidad Nacional de Colombia, Bogota, D.C. (Colombia)
Publication Date:
OSTI Identifier:
22608529
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1753; Journal Issue: 1; Conference: Latin American symposium on nuclear physics and applications, Medellin (Colombia), 30 Nov - 4 Dec 2015; Other Information: (c) 2016 Author(s); Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOMEDICAL RADIOGRAPHY; DETECTION; DOSIMETRY; EMISSION; GALLIUM 68; HUMAN POPULATIONS; IMPURITIES; NEOPLASMS; POSITRON COMPUTED TOMOGRAPHY; POSITRONS; PROSTATE; RADIOPHARMACEUTICALS; SYNTHESIS; TOXICITY; TRACER TECHNIQUES; UREA

Citation Formats

Parra, Pamela Ochoa, E-mail: lapochoap@unal.edu.co, and Veloza, Stella. Scaling animal to human biodistribution of the radiopharmaceutical [68Ga]Ga-PSMA-HBED-CC. United States: N. p., 2016. Web. doi:10.1063/1.4955383.
Parra, Pamela Ochoa, E-mail: lapochoap@unal.edu.co, & Veloza, Stella. Scaling animal to human biodistribution of the radiopharmaceutical [68Ga]Ga-PSMA-HBED-CC. United States. doi:10.1063/1.4955383.
Parra, Pamela Ochoa, E-mail: lapochoap@unal.edu.co, and Veloza, Stella. Thu . "Scaling animal to human biodistribution of the radiopharmaceutical [68Ga]Ga-PSMA-HBED-CC". United States. doi:10.1063/1.4955383.
@article{osti_22608529,
title = {Scaling animal to human biodistribution of the radiopharmaceutical [68Ga]Ga-PSMA-HBED-CC},
author = {Parra, Pamela Ochoa, E-mail: lapochoap@unal.edu.co and Veloza, Stella},
abstractNote = {The radiotracer called {sup 68}Ga-labelled Glu-urea-Lys(Ahx)-HBED-CC ([68Ga]Ga-PSMA-HBED-CC) is a novel radiophar-maceutical for the detection of prostate cancer lesions by positron emission tomography (PET) imaging. Setting up a cost-effective manual synthesis of this radiotracer and making its clinical translation in Colombia will require two important elements: the evaluation of the procedure to yield a consistent product, meeting standards of radio-chemical purity and low toxicity and then, the evaluation of the radiation dosimetry. In this paper a protocol to extrapolate the biokinetic model made in normal mice to humans by using the computer software for internal dose assessment OLINDA/EXM® is presented as an accurate and standardized method for the calculation of radiation dosimetry estimates.},
doi = {10.1063/1.4955383},
journal = {AIP Conference Proceedings},
number = 1,
volume = 1753,
place = {United States},
year = {Thu Jul 07 00:00:00 EDT 2016},
month = {Thu Jul 07 00:00:00 EDT 2016}
}