Optimized spray drying process for preparation of one-step calcium-alginate gel microspheres

Journal Article · Fri Mar 25 00:00:00 EDT 2016 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.4944310· OSTI ID:22591047

Popeski-Dimovski, Riste ^[1]

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1. Department of physic, Faculty of Natural Sciences and Mathematics, “ss. Cyril and Methodius” University, Arhimedova 3, 1000 Skopje, R. Macedonia (Macedonia, The Former Yugoslav Republic of)

Calcium-alginate micro particles have been used extensively in drug delivery systems. Therefore we establish a one-step method for preparation of internally gelated micro particles with spherical shape and narrow size distribution. We use four types of alginate with different G/M ratio and molar weight. The size of the particles is measured using light diffraction and scanning electron microscopy. Measurements showed that with this method, micro particles with size distribution around 4 micrometers can be prepared, and SEM imaging showed that those particles are spherical in shape.

• OSTI ID: 22591047
• Journal Information: AIP Conference Proceedings, Vol. 1722, Issue 1; Conference: BPU-9: 9. international physics conference of the Balkan Physical Union, Istanbul (Turkey), 24-27 Aug 2015; Other Information: (c) 2016 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

71 CLASSICAL AND QUANTUM MECHANICS
GENERAL PHYSICS
ALGINATES
CALCIUM
DIFFRACTION
GELS
MICROSPHERES
PARTICLE SIZE
PARTICLES
SCANNING ELECTRON MICROSCOPY
SPHERICAL CONFIGURATION
SPRAY DRYING
SPRAYS
VISIBLE RADIATION