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Title: SU-E-T-640: Proton Modulated Arc Therapy Using Scanned Pencil Beams

Abstract

Purpose: Rotational proton radiotherapy would be an interesting treatment modality if it proves to produce dose distributions that conform to the target as well or better than currently available treatment modalities, while reducing the dose to the surrounding organs at risk. A treatment planning study is presented, showing how this objective can be achieved using a single or small number of scanned mono-energetic pencil beams delivered while the proton gantry rotates at the same time that they may deliver faster and more biologically effective treatments than current proton modalities.Methods Proton treatment using single- (SFO) and multi-field optimized (MFO) PBS plans are compared with PMAT plans in phantoms of different shape and uniformity as well as on a brain case. The method followed in ECLIPSE to produce PMAT plans is presented and the feasibility is discussed. Results Table 1 shows that the conformity and uniformity of the PMAT plans is of similar order than those of the SFO and MFO plans. However, in the brain case, the DVHs shown in Figure 1 indicate a significant reduction of the dose to the OARs when PMAT is used. Similarly, the use of PMAT increases the LET in the treatment area, which could translatemore » into a more biologically effective treatment.Conclusions PMAT could provide dose distributions as conformal as current PBS plans but could also offer faster beam delivery and more biologically effective proton plans.« less

Authors:
; ; ; ; ; ;  [1]
  1. Hospital of the University of Pennsylvania, Philadelphia, PA (United States)
Publication Date:
OSTI Identifier:
22538149
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 42; Journal Issue: 6; Other Information: (c) 2015 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; PHANTOMS; PROTON BEAMS; RADIATION DOSE DISTRIBUTIONS; RADIOTHERAPY

Citation Formats

Carabe-Fernandez, A, Kirk, M, Sanchez-Parcerisa, D, Fager, M, Burgdorf, B, Stowe, M, and Solberg, T. SU-E-T-640: Proton Modulated Arc Therapy Using Scanned Pencil Beams. United States: N. p., 2015. Web. doi:10.1118/1.4925003.
Carabe-Fernandez, A, Kirk, M, Sanchez-Parcerisa, D, Fager, M, Burgdorf, B, Stowe, M, & Solberg, T. SU-E-T-640: Proton Modulated Arc Therapy Using Scanned Pencil Beams. United States. doi:10.1118/1.4925003.
Carabe-Fernandez, A, Kirk, M, Sanchez-Parcerisa, D, Fager, M, Burgdorf, B, Stowe, M, and Solberg, T. Mon . "SU-E-T-640: Proton Modulated Arc Therapy Using Scanned Pencil Beams". United States. doi:10.1118/1.4925003.
@article{osti_22538149,
title = {SU-E-T-640: Proton Modulated Arc Therapy Using Scanned Pencil Beams},
author = {Carabe-Fernandez, A and Kirk, M and Sanchez-Parcerisa, D and Fager, M and Burgdorf, B and Stowe, M and Solberg, T},
abstractNote = {Purpose: Rotational proton radiotherapy would be an interesting treatment modality if it proves to produce dose distributions that conform to the target as well or better than currently available treatment modalities, while reducing the dose to the surrounding organs at risk. A treatment planning study is presented, showing how this objective can be achieved using a single or small number of scanned mono-energetic pencil beams delivered while the proton gantry rotates at the same time that they may deliver faster and more biologically effective treatments than current proton modalities.Methods Proton treatment using single- (SFO) and multi-field optimized (MFO) PBS plans are compared with PMAT plans in phantoms of different shape and uniformity as well as on a brain case. The method followed in ECLIPSE to produce PMAT plans is presented and the feasibility is discussed. Results Table 1 shows that the conformity and uniformity of the PMAT plans is of similar order than those of the SFO and MFO plans. However, in the brain case, the DVHs shown in Figure 1 indicate a significant reduction of the dose to the OARs when PMAT is used. Similarly, the use of PMAT increases the LET in the treatment area, which could translate into a more biologically effective treatment.Conclusions PMAT could provide dose distributions as conformal as current PBS plans but could also offer faster beam delivery and more biologically effective proton plans.},
doi = {10.1118/1.4925003},
journal = {Medical Physics},
number = 6,
volume = 42,
place = {United States},
year = {Mon Jun 15 00:00:00 EDT 2015},
month = {Mon Jun 15 00:00:00 EDT 2015}
}