Gain and frequency tuning within the mouse cochlear apex

Journal Article · Thu Dec 31 04:00:00 EST 2015 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.4939339· OSTI ID:22496249

Oghalai, John S.; Raphael, Patrick D. ^[1]; Gao, Simon ^[1]; Lee, Hee Yoon ^[1]; Groves, Andrew K. ^[2]; Zuo, Jian ^[3]; Applegate, Brian E. ^[4]

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1. Department of Otolaryngology, Stanford University School of Medicine, Stanford, California (United States)
2. Department of Neuroscience, Department of Molecular and Human Genetics, and Program in Developmental Biology, Baylor College of Medicine, Houston, Texas (United States)
3. Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee (United States)
4. Department of Biomedical Engineering, Texas A&M University, College Station, Texas (United States)

Normal mammalian hearing requires cochlear outer hair cell active processes that amplify the traveling wave with high gain and sharp tuning, termed cochlear amplification. We have used optical coherence tomography to study cochlear amplification within the apical turn of the mouse cochlea. We measured not only classical basilar membrane vibratory tuning curves but also vibratory responses from the rest of the tissues that compose the organ of Corti. Basilar membrane tuning was sharp in live mice and broad in dead mice, whereas other regions of the organ of Corti demonstrated phase shifts consistent with additional filtering beyond that provided by basilar membrane mechanics. We use these experimental data to support a conceptual framework of how cochlear amplification is tuned within the mouse cochlear apex. We will also study transgenic mice with targeted mutations that affect different biomechanical aspects of the organ of Corti in an effort to localize the underlying processes that produce this additional filtering.

• OSTI ID: 22496249
• Journal Information: AIP Conference Proceedings, Journal Name: AIP Conference Proceedings Journal Issue: 1 Vol. 1703; ISSN APCPCS; ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

71 CLASSICAL AND QUANTUM MECHANICS
GENERAL PHYSICS
ANIMAL TISSUES
DIAGRAMS
FILTERS
GAIN
HAIR
MECHANICS
MEMBRANES
MUTATIONS
PHASE SHIFT
PLANT TISSUES
TOMOGRAPHY
TRANSGENIC MICE
TRAVELLING WAVES
TUNING
WAVE PROPAGATION