Green synthesis of chalcones derivatives as intermediate of flavones and their antibacterial activities

Journal Article · Mon Feb 08 04:00:00 UTC 2016 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.4941514· OSTI ID:22494624

Redjeki, Tri ^[1]; Matsjeh, Sabirin; Mustofa, ^[2]

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1. Universitas Sebelas Maret, Ir Sutami 36A Surakarta Indonesia, 57126 (Indonesia)
2. Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta Jl. Sekip Utara Yogyakarta Indonesia, 55281 (Indonesia)

Four chalcones derivatives have been synthesized from 3,4-dimethoxybenzaldehyde and acetophenone derivatives (2-hydroxy acetophenone, 2,4-dihydroxy acetophenone, 2,5-dihydroxy acetophenone and 2,6-dihydroxy acetophenone). The synthesis of these chalcones were conducted by Claisen-Schmidt condensation using grinding techniques at room temperature in the absence of solvents. The chalcones were prepared by grinding together equivalent amount of the approriate hydroxyacetophenone and 3,4-dimethoxybenzaldehyde in the presence of solid sodium hydroxide. Grinding techniques for synthesis of the chalcones derivatives is simple, efficient and environmentally benign compared to conventional methods. Then, the four chalcones derivatives undergo cyclization reactions to produce four flavones after reacted with iodine. The synthesized compounds were characterized by spectrometry (IR, {sup 1}H-NMR, {sup 13}C-NMR and MS)

• OSTI ID: 22494624
• Journal Information: AIP Conference Proceedings, Journal Name: AIP Conference Proceedings Journal Issue: 1 Vol. 1710; ISSN APCPCS; ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
ACETOPHENONE
CARBON 13
CYCLIZATION
FLAVONES
GRINDING
HYDROGEN 1
IODINE
NUCLEAR MAGNETIC RESONANCE
SODIUM HYDROXIDES
SOLVENTS
SPECTROSCOPY
SYNTHESIS
TEMPERATURE RANGE 0273-0400 K