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Title: An absolute calibration method of an ethyl alcohol biosensor based on wavelength-modulated differential photothermal radiometry

Abstract

In this work, laser-based wavelength-modulated differential photothermal radiometry (WM-DPTR) is applied to develop a non-invasive in-vehicle alcohol biosensor. WM-DPTR features unprecedented ethanol-specificity and sensitivity by suppressing baseline variations through a differential measurement near the peak and baseline of the mid-infrared ethanol absorption spectrum. Biosensor signal calibration curves are obtained from WM-DPTR theory and from measurements in human blood serum and ethanol solutions diffused from skin. The results demonstrate that the WM-DPTR-based calibrated alcohol biosensor can achieve high precision and accuracy for the ethanol concentration range of 0-100 mg/dl. The high-performance alcohol biosensor can be incorporated into ignition interlocks that could be fitted as a universal accessory in vehicles in an effort to reduce incidents of drinking and driving.

Authors:
;  [1];  [2];  [1]
  1. Department of Mechanical and Industrial Engineering, Center for Advanced Diffusion-Wave Technologies (CADIFT), University of Toronto, Toronto, Ontario M5S 3G8 (Canada)
  2. (Canada)
Publication Date:
OSTI Identifier:
22482613
Resource Type:
Journal Article
Resource Relation:
Journal Name: Review of Scientific Instruments; Journal Volume: 86; Journal Issue: 11; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; ABSORPTION SPECTRA; ACCURACY; BLOOD SERUM; CALIBRATION; DIAGRAMS; ETHANOL; SKIN; SOLUTIONS

Citation Formats

Liu, Yi Jun, Mandelis, Andreas, E-mail: mandelis@mie.utoronto.ca, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, and Guo, Xinxin. An absolute calibration method of an ethyl alcohol biosensor based on wavelength-modulated differential photothermal radiometry. United States: N. p., 2015. Web. doi:10.1063/1.4935308.
Liu, Yi Jun, Mandelis, Andreas, E-mail: mandelis@mie.utoronto.ca, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, & Guo, Xinxin. An absolute calibration method of an ethyl alcohol biosensor based on wavelength-modulated differential photothermal radiometry. United States. doi:10.1063/1.4935308.
Liu, Yi Jun, Mandelis, Andreas, E-mail: mandelis@mie.utoronto.ca, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, and Guo, Xinxin. Sun . "An absolute calibration method of an ethyl alcohol biosensor based on wavelength-modulated differential photothermal radiometry". United States. doi:10.1063/1.4935308.
@article{osti_22482613,
title = {An absolute calibration method of an ethyl alcohol biosensor based on wavelength-modulated differential photothermal radiometry},
author = {Liu, Yi Jun and Mandelis, Andreas, E-mail: mandelis@mie.utoronto.ca and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9 and Guo, Xinxin},
abstractNote = {In this work, laser-based wavelength-modulated differential photothermal radiometry (WM-DPTR) is applied to develop a non-invasive in-vehicle alcohol biosensor. WM-DPTR features unprecedented ethanol-specificity and sensitivity by suppressing baseline variations through a differential measurement near the peak and baseline of the mid-infrared ethanol absorption spectrum. Biosensor signal calibration curves are obtained from WM-DPTR theory and from measurements in human blood serum and ethanol solutions diffused from skin. The results demonstrate that the WM-DPTR-based calibrated alcohol biosensor can achieve high precision and accuracy for the ethanol concentration range of 0-100 mg/dl. The high-performance alcohol biosensor can be incorporated into ignition interlocks that could be fitted as a universal accessory in vehicles in an effort to reduce incidents of drinking and driving.},
doi = {10.1063/1.4935308},
journal = {Review of Scientific Instruments},
number = 11,
volume = 86,
place = {United States},
year = {Sun Nov 15 00:00:00 EST 2015},
month = {Sun Nov 15 00:00:00 EST 2015}
}