Interactions between N-acetyl-L-cysteine protected CdTe quantum dots and doxorubicin through spectroscopic method

Journal Article · Mon Jun 15 04:00:00 EDT 2015 · Materials Research Bulletin

DOI:https://doi.org/10.1016/J.MATERRESBULL.2015.02.050· OSTI ID:22475801

Yang, Xiupei ^[1]; Lin, Jia; Liao, Xiulin; Zong, Yingying; Gao, Huanhuan ^[2]

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1. Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, Nanchong 637000 (China)
2. College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637000 (China)

Highlights: • CdTe quantum dots with the diameter of 3–5 nm were synthesized in aqueous solution. • The modified CdTe quantum dots showed well fluorescence properties. • The interaction between the CdTe quantum dots and doxorubicin (DR) was investigated. - Abstract: N-acetyl-L-cysteine protected cadmium telluride quantum dots with a diameter of 3–5 nm were synthesized in aqueous solution. The interaction between N-acetyl-L-cysteine/cadmium telluride quantum dots and doxorubicin was investigated by ultraviolet–visible absorption and fluorescence spectroscopy at physiological conditions (pH 7.2, 37 °C). The results indicate that electron transfer has occurred between N-acetyl-L-cysteine/cadmium telluride quantum dots and doxorubicin under light illumination. The quantum dots react readily with doxorubicin to form a N-acetyl-L-cysteine/cadmium telluride-quantum dots/doxorubicin complex via electrostatic attraction between the −NH{sub 3}{sup +} moiety of doxorubicin and the −COO{sup −} moiety of N-acetyl-L-cysteine/cadmium telluride quantum dots. The interaction of N-acetyl-L-cysteine/cadmium telluride-quantum dots/doxorubicin complex with bovine serum albumin was studied as well, showing that the complex might induce the conformation change of bovine serum due to changes in microenvironment of bovine serum.

• OSTI ID: 22475801
• Journal Information: Materials Research Bulletin, Journal Name: Materials Research Bulletin Vol. 66; ISSN MRBUAC; ISSN 0025-5408
• Country of Publication: United States
• Language: English

Related Subjects

75 CONDENSED MATTER PHYSICS
SUPERCONDUCTIVITY AND SUPERFLUIDITY
ABSORPTION
AQUEOUS SOLUTIONS
CADMIUM TELLURIDES
CYSTEINE
DOXORUBICIN
ELECTRON TRANSFER
FLUORESCENCE
FLUORESCENCE SPECTROSCOPY
ILLUMINANCE
INTERACTIONS
OPTICAL PROPERTIES
PH VALUE
QUANTUM DOTS
TRANSMISSION ELECTRON MICROSCOPY
ULTRAVIOLET RADIATION
VISIBLE RADIATION