Evaluation of a Thermoprotective Gel for Hydrodissection During Percutaneous Microwave Ablation: In Vivo Results

Journal Article · Mon Jun 15 00:00:00 EDT 2015 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-014-1008-9· OSTI ID:22469952

Moreland, Anna J., E-mail: [e-mail]; Lubner, Meghan G., E-mail: [e-mail]; Ziemlewicz, Timothy J., E-mail: [e-mail]; Kitchin, Douglas R., E-mail: [e-mail]; Hinshaw, J. Louis, E-mail: [e-mail]; Johnson, Alexander D., E-mail: [e-mail]; Lee, Fred T., E-mail: [e-mail]; Brace, Christopher L., E-mail: [e-mail] ^[1]

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1. University of Wisconsin – Madison, Department of Radiology, E3/366 Clinical Science Center (United States)

PurposeTo evaluate whether thermoreversible poloxamer 407 15.4 % in water (P407) can protect non-target tissues adjacent to microwave (MW) ablation zones in a porcine model.Materials and MethodsMW ablation antennas were placed percutaneously into peripheral liver, spleen, or kidney (target tissues) under US and CT guidance in five swine such that the expected ablation zones would extend into adjacent diaphragm, body wall, or bowel (non-target tissues). For experimental ablations, P407 (a hydrogel that transitions from liquid at room temperature to semi-solid at body temperature) was injected into the potential space between target and non-target tissues, and the presence of a gel barrier was verified on CT. No barrier was used for controls. MW ablation was performed at 65 W for 5 min. Thermal damage to target and non-target tissues was evaluated at dissection.ResultsAntennas were placed 7 ± 3 mm from the organ surface for both control and gel-protected ablations (p = 0.95). The volume of gel deployed was 49 ± 27 mL, resulting in a barrier thickness of 0.8 ± 0.5 cm. Ablations extended into non-target tissues in 12/14 control ablations (mean surface area = 3.8 cm{sup 2}) but only 4/14 gel-protected ablations (mean surface area = 0.2 cm{sup 2}; p = 0.0005). The gel barrier remained stable at the injection site throughout power delivery.ConclusionWhen used as a hydrodissection material, P407 protected non-targeted tissues and was successfully maintained at the injection site for the duration of power application. Continued investigations to aid clinical translation appear warranted.

• OSTI ID: 22469952
• Journal Information: Cardiovascular and Interventional Radiology, Vol. 38, Issue 3; Conference: CIRSE 2015: Cardiovascular and Interventional Radiological Society of Europe congress, Lisbon (Portugal), 26-30 Sep 2015; Other Information: Copyright (c) 2015 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); ISSN 0174-1551
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ABLATION
ADMINISTRATIVE PROCEDURES
ANIMAL TISSUES
ANTENNAS
BODY TEMPERATURE
COMPUTERIZED TOMOGRAPHY
DAMAGE
DELIVERY
DIAPHRAGM
EVALUATION
IN VIVO
INJECTION
KIDNEYS
LIVER
MATERIALS
MICROWAVE RADIATION
POTENTIALS
SOLIDS
SPACE
SPLEEN
SURFACES
SWINE
THICKNESS
VENTILATION BARRIERS
WALLS
WATER
ZONES