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Title: Early Stage Hepatocellular Carcinomas Not Feasible for Ultrasound-Guided Radiofrequency Ablation: Comparison of Transarterial Chemoembolization Alone and Combined Therapy with Transarterial Chemoembolization and Radiofrequency Ablation

Abstract

PurposeTo report the results of combined therapy with transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) for early stage hepatocellular carcinoma (HCC) considered infeasible for ultrasound (US)-guided RFA in comparison with those of TACE monotherapy.MethodsFrom January 2007 through December 2010, 91 patients with early or very early stage HCC infeasible for US-guided RFA received either TACE alone (TACE group; n = 54) or TACE immediately followed by RFA (TACE–RFA group; n = 37) as a first-line treatment. 1-month tumor response, time to progression (TTP), and overall survival (OS) rates were calculated. Univariate and multivariate analyses were performed to identify prognostic factors.ResultsTACE–RFA group showed a better 1-month tumor response than TACE group (P < .001). The mean TTP was 29.7 ± 3.4 months (95 % confidence intervals [CIs] 23.0–36.5) in TACE group and 34.9 ± 2.8 months (95 % CIs 29.4–40.4) in TACE–RFA group. TACE–RFA group had a significantly longer TTP (P = .014). Cumulative 1-, 2-, and 3-year OS rates in the TACE and TACE–RFA groups were 91, 79, and 71 % and 100, 97, and 93 %, respectively (P = .008). Initial treatment of TACE was found to be the only significant risk factor for tumor progression and OS in multivariate analysis.ConclusionTACE–RFA combination therapy appears superior to TACE monotherapy in terms of 1-month tumor response, TTP, and OS when performedmore » for early stage HCC infeasible for US-guided RFA.« less

Authors:
; ; ; ; ; ; ; ; ;  [1]
  1. Sungkyunkwan University School of Medicine, Department of Radiology and Center for Imaging Science, Samsung Medical Center (Korea, Republic of)
Publication Date:
OSTI Identifier:
22469575
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 39; Journal Issue: 3; Other Information: Copyright (c) 2016 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ABLATION; COMBINED THERAPY; COMPARATIVE EVALUATIONS; HAZARDS; HEPATOMAS; MULTIVARIATE ANALYSIS; PATIENTS; RADIOWAVE RADIATION

Citation Formats

Hyun, Dongho, Cho, Sung Ki, E-mail: chosk@skku.edu, Shin, Sung Wook, Park, Kwang Bo, Park, Hong Suk, Choo, Sung Wook, Do, Young Soo, Choo, In-wook, Lee, Min Woo, Rhim, Hyunchul, and Lim, Hyo Keun. Early Stage Hepatocellular Carcinomas Not Feasible for Ultrasound-Guided Radiofrequency Ablation: Comparison of Transarterial Chemoembolization Alone and Combined Therapy with Transarterial Chemoembolization and Radiofrequency Ablation. United States: N. p., 2016. Web. doi:10.1007/S00270-015-1194-0.
Hyun, Dongho, Cho, Sung Ki, E-mail: chosk@skku.edu, Shin, Sung Wook, Park, Kwang Bo, Park, Hong Suk, Choo, Sung Wook, Do, Young Soo, Choo, In-wook, Lee, Min Woo, Rhim, Hyunchul, & Lim, Hyo Keun. Early Stage Hepatocellular Carcinomas Not Feasible for Ultrasound-Guided Radiofrequency Ablation: Comparison of Transarterial Chemoembolization Alone and Combined Therapy with Transarterial Chemoembolization and Radiofrequency Ablation. United States. doi:10.1007/S00270-015-1194-0.
Hyun, Dongho, Cho, Sung Ki, E-mail: chosk@skku.edu, Shin, Sung Wook, Park, Kwang Bo, Park, Hong Suk, Choo, Sung Wook, Do, Young Soo, Choo, In-wook, Lee, Min Woo, Rhim, Hyunchul, and Lim, Hyo Keun. Tue . "Early Stage Hepatocellular Carcinomas Not Feasible for Ultrasound-Guided Radiofrequency Ablation: Comparison of Transarterial Chemoembolization Alone and Combined Therapy with Transarterial Chemoembolization and Radiofrequency Ablation". United States. doi:10.1007/S00270-015-1194-0.
@article{osti_22469575,
title = {Early Stage Hepatocellular Carcinomas Not Feasible for Ultrasound-Guided Radiofrequency Ablation: Comparison of Transarterial Chemoembolization Alone and Combined Therapy with Transarterial Chemoembolization and Radiofrequency Ablation},
author = {Hyun, Dongho and Cho, Sung Ki, E-mail: chosk@skku.edu and Shin, Sung Wook and Park, Kwang Bo and Park, Hong Suk and Choo, Sung Wook and Do, Young Soo and Choo, In-wook and Lee, Min Woo and Rhim, Hyunchul and Lim, Hyo Keun},
abstractNote = {PurposeTo report the results of combined therapy with transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) for early stage hepatocellular carcinoma (HCC) considered infeasible for ultrasound (US)-guided RFA in comparison with those of TACE monotherapy.MethodsFrom January 2007 through December 2010, 91 patients with early or very early stage HCC infeasible for US-guided RFA received either TACE alone (TACE group; n = 54) or TACE immediately followed by RFA (TACE–RFA group; n = 37) as a first-line treatment. 1-month tumor response, time to progression (TTP), and overall survival (OS) rates were calculated. Univariate and multivariate analyses were performed to identify prognostic factors.ResultsTACE–RFA group showed a better 1-month tumor response than TACE group (P < .001). The mean TTP was 29.7 ± 3.4 months (95 % confidence intervals [CIs] 23.0–36.5) in TACE group and 34.9 ± 2.8 months (95 % CIs 29.4–40.4) in TACE–RFA group. TACE–RFA group had a significantly longer TTP (P = .014). Cumulative 1-, 2-, and 3-year OS rates in the TACE and TACE–RFA groups were 91, 79, and 71 % and 100, 97, and 93 %, respectively (P = .008). Initial treatment of TACE was found to be the only significant risk factor for tumor progression and OS in multivariate analysis.ConclusionTACE–RFA combination therapy appears superior to TACE monotherapy in terms of 1-month tumor response, TTP, and OS when performed for early stage HCC infeasible for US-guided RFA.},
doi = {10.1007/S00270-015-1194-0},
journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 3,
volume = 39,
place = {United States},
year = {2016},
month = {3}
}