Combined impact of lead, cadmium, polychlorinated biphenyls and non-chemical risk factors on blood pressure in NHANES

Journal Article · Tue Jul 15 00:00:00 EDT 2014 · Environmental Research

DOI:https://doi.org/10.1016/J.ENVRES.2014.03.038· OSTI ID:22447529

Peters, Junenette L., E-mail: [e-mail]; Patricia Fabian, M., E-mail: [e-mail]; Levy, Jonathan I., E-mail: [e-mail]

High blood pressure is associated with exposure to multiple chemical and non-chemical risk factors, but epidemiological analyses to date have not assessed the combined effects of both chemical and non-chemical stressors on human populations in the context of cumulative risk assessment. We developed a novel modeling approach to evaluate the combined impact of lead, cadmium, polychlorinated biphenyls (PCBs), and multiple non-chemical risk factors on four blood pressure measures using data for adults aged ≥20 years from the National Health and Nutrition Examination Survey (1999–2008). We developed predictive models for chemical and other stressors. Structural equation models were applied to account for complex associations among predictors of stressors as well as blood pressure. Models showed that blood lead, serum PCBs, and established non-chemical stressors were significantly associated with blood pressure. Lead was the chemical stressor most predictive of diastolic blood pressure and mean arterial pressure, while PCBs had a greater influence on systolic blood pressure and pulse pressure, and blood cadmium was not a significant predictor of blood pressure. The simultaneously fit exposure models explained 34%, 43% and 52% of the variance for lead, cadmium and PCBs, respectively. The structural equation models were developed using predictors available from public data streams (e.g., U.S. Census), which would allow the models to be applied to any U.S. population exposed to these multiple stressors in order to identify high risk subpopulations, direct intervention strategies, and inform public policy. - Highlights: • We evaluated joint impact of chemical and non-chemical stressors on blood pressure. • We built predictive models for lead, cadmium and polychlorinated biphenyls (PCBs). • Our approach allows joint evaluation of predictors from population-specific data. • Lead, PCBs and established non-chemical stressors were related to blood pressure. • Framework allows cumulative risk assessment in specific geographic settings.

• OSTI ID: 22447529
• Journal Information: Environmental Research, Vol. 132; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
APPROXIMATIONS
BLOOD
BLOOD PRESSURE
BONNEVILLE POWER ADMINISTRATION
CADMIUM
COMPLEXES
DATES
DBP
DIOXIN
ELDERLY PEOPLE
EQUATIONS
EVALUATION
HAZARDS
LEAD
MAPS
MARINE SURVEYS
NUTRITION
POLYCHLORINATED BIPHENYLS
PUBLIC OPINION
PUBLIC POLICY
PULSES
RISK ASSESSMENT
ROOTS
SCANNING ELECTRON MICROSCOPY
SIMULATION
STATISTICS
STREAMS